{"id":"W4415435698","doi":"10.1038/s41380-025-03304-6","title":"Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study","year":2025,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas College; Child, Adolescent and Family Mental Health","funders":"Moonshot Research and Development Program; Janssen Pharmaceuticals; National Institute of Mental Health; Japan Society for the Promotion of Science; National Medical Research Council; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; National University Health System; Norges Forskningsråd; Meiji Seika Pharma; Astellas Pharma; Vetenskapsrådet; National Natural Science Foundation of China; Eisai; Consejo Nacional de Ciencia y Tecnología; Medical Center, University of Pittsburgh; Bundesministerium für Bildung und Forschung; Russian Foundation for Basic Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Naito Foundation; Japan Agency for Medical Research and Development; Deutsche Forschungsgemeinschaft; Medical Research Council; National Research Foundation of Korea; Region Hovedstaden; Agency for Science, Technology and Research; Instituto de Salud Carlos III; National University of Singapore; National Research Foundation; Korea Brain Research Institute; Sistema Nacional de Investigadores; European Commission; Fundación Alicia Koplowitz; Helse Sør-Øst RHF; University of Pittsburgh; Lundbeckfonden; Eli Lilly and Company; Karolinska Institutet; National Alliance for Research on Schizophrenia and Depression; Ministry of Education, India; Biogen; Brain and Behavior Research Foundation; National Science Foundation","keywords":"Optimal distinctiveness theory; Psychosis; Neuroimaging; Network topology; Grey matter; Covariance; Network analysis; Cluster analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001038745,0.0003674673,0.0004516943,0.0007507803,0.001165332,0.001061039,0.000804767,0.0008482582,0.005330122],"category_scores_gemma":[0.007560564,0.0004220194,0.0005250408,0.001120178,0.0007137022,0.001294876,0.001379093,0.001076614,0.0004098366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307399,"about_ca_system_score_gemma":0.0004500622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008905039,"about_ca_topic_score_gemma":0.01146609,"domain_scores_codex":[0.9996451,0.0001284035,0.00001983773,0.0001251816,0.00003360772,0.00004786689],"domain_scores_gemma":[0.9973247,0.0007614918,0.0007809053,0.0006033186,0.0002252159,0.000304359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001441446,0.0002306299,0.9796838,0.00006827225,0.001007905,0.0007013817,0.001606559,0.0006963762,0.003067826,0.002318437,0.001504041,0.007673413],"study_design_scores_gemma":[0.00004918843,0.0001318396,0.9919372,0.00002174035,0.0002860095,0.001316361,0.0009344197,0.001424241,0.0001754265,0.00311481,0.0005858055,0.00002303418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983063,0.000098287,0.0003726968,0.000178506,0.000006342337,0.00000661551,0.0005291851,0.000005581826,0.0004966324],"genre_scores_gemma":[0.9989717,0.00005239228,0.0002655411,0.00003062678,0.000008621768,0.000009937411,0.0003686939,0.00001013771,0.0002823171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008905039,"threshold_uncertainty_score":0.01783103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02568900387115764,"score_gpt":0.3376067570763591,"score_spread":0.3119177532052014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}