{"id":"W4415442974","doi":"10.1182/bloodadvances.2025017837","title":"Molecular risk markers define risk of relapse in myeloid leukemia of Down syndrome beyond measurable residual disease","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hospital for Sick Children; Agricultural Research Institute of Ontario; Children's Hospital of Eastern Ontario","funders":"National Institutes of Health","keywords":"Myeloid leukemia; Minimal residual disease; Down syndrome; Chemotherapy; Disease; Leukemia; Myeloid; Induction chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004754818,0.0001977819,0.0002289005,0.0003487121,0.00008718716,0.0002892927,0.0001906862,0.0002456227,0.0007673904],"category_scores_gemma":[0.0018151,0.00008486233,0.0002562905,0.0002868131,0.0001232807,0.000181969,0.0002303501,0.0002921868,0.00009697511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737183,"about_ca_system_score_gemma":0.000136266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005703818,"about_ca_topic_score_gemma":0.0004527032,"domain_scores_codex":[0.9997697,0.00009044792,0.00002590579,0.00003902934,0.00004522847,0.00002969824],"domain_scores_gemma":[0.9990479,0.0002901419,0.0004221237,0.00003142984,0.00005921251,0.000149182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008868767,0.00002650637,0.9929491,0.00001177416,0.00004868038,0.00006149968,0.00001957094,0.0001446224,0.001878843,0.00003173422,0.00006676937,0.00387394],"study_design_scores_gemma":[0.00004226855,0.000450497,0.9968837,0.000006420029,0.00008610031,0.000533475,0.00003684085,0.0007934273,0.0008706797,0.00004397439,0.0002485438,0.000004047749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994918,0.0002180616,0.00008813402,0.00001519144,0.00000231871,0.000004209349,0.00005399242,0.000001739545,0.000124509],"genre_scores_gemma":[0.9997074,0.00003467502,0.0001196849,0.000009199581,0.000003078011,0.000003071408,0.00008677186,7.360715e-7,0.00003543599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007673904,"threshold_uncertainty_score":0.002567112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005439864185806042,"score_gpt":0.2533660069236029,"score_spread":0.2479261427377968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}