{"id":"W4415444204","doi":"10.1158/1535-7163.targ-25-c122","title":"Abstract C122: Effects of standard-of-care therapies on tumor growth, tumor-induced bone loss and bone pain in preclinical models of breast and prostate cancer bone metastasis and multiple myeloma bone disease","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Prostate cancer; Breast cancer; Multiple myeloma; Bone metastasis; Bone marrow; Bone pain; Bortezomib; Bone disease; Zoledronic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003160715,0.0007463928,0.0008029317,0.0006011829,0.000275804,0.0003879524,0.0005017013,0.0007431967,0.003263748],"category_scores_gemma":[0.0001873265,0.0002037601,0.0006941913,0.000492351,0.0003670965,0.0002117105,0.0001832893,0.002002878,0.0006150365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005147362,"about_ca_system_score_gemma":0.0007539457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002902851,"about_ca_topic_score_gemma":0.005086759,"domain_scores_codex":[0.9994705,0.00007058962,0.00003825054,0.00008035321,0.000200433,0.0001399233],"domain_scores_gemma":[0.9996606,0.00002907669,0.00007783336,0.00003018081,0.00006698626,0.0001353303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005101456,0.004634081,0.0003650028,0.0003440252,0.00004614898,0.0001620472,0.0000588452,0.0007922684,0.9784213,0.0002631398,0.001612077,0.008199505],"study_design_scores_gemma":[0.0007604337,0.04238689,0.007540138,0.00004677001,0.0001057488,0.000364738,0.0001018879,0.002741211,0.9357435,0.0001111924,0.01005758,0.00003989106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852813,0.004394372,0.001889944,0.0004279535,0.000300481,0.0003683751,0.002755822,0.0002459122,0.004335853],"genre_scores_gemma":[0.978724,0.002558606,0.003135625,0.0002893401,0.00007240944,0.0006375717,0.003969129,0.0000512695,0.01056198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003263748,"threshold_uncertainty_score":0.01091832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186134890478176,"score_gpt":0.3244242501796867,"score_spread":0.302562901274905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}