{"id":"W4415444529","doi":"10.1158/1535-7163.targ-25-c108","title":"Abstract C108: The therapeutic candidate antibody PODO447 recognizes a glycopeptide on podocalyxin-expressing tumor cells that have undergone a partial epithelial-mesenchymal transition","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Epitope; Monoclonal antibody; Antibody; Transmembrane protein; Phenotype; Glycopeptide; Cell sorting; MUC1; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117507,0.0003324977,0.0002252133,0.0002350775,0.0001537501,0.0002119405,0.0002696626,0.0005806831,0.007921744],"category_scores_gemma":[0.0001166912,0.00008975882,0.0001984013,0.0001134933,0.0001411106,0.0001505793,0.0001409606,0.0008440744,0.001385268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004246253,"about_ca_system_score_gemma":0.0002469415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001160844,"about_ca_topic_score_gemma":0.0009462139,"domain_scores_codex":[0.9998666,0.0000176244,0.000006656047,0.00002066884,0.00004249906,0.00004584179],"domain_scores_gemma":[0.9999399,0.000008436778,0.000006936186,0.000004742697,0.00001363354,0.00002641785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004922912,0.0002925976,0.0009944708,0.00005665283,0.00001535359,0.0001701887,0.00001310125,0.0001314362,0.9884013,0.0001953124,0.001378063,0.007859282],"study_design_scores_gemma":[0.0001874907,0.002492239,0.008562646,0.00001928006,0.00005190031,0.001320998,0.0000277392,0.002500097,0.9726783,0.0001115474,0.01203954,0.000008249939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984795,0.001372109,0.002415532,0.0005895339,0.0001160974,0.0001611945,0.0006445574,0.0001306838,0.009775296],"genre_scores_gemma":[0.9844519,0.0004544836,0.0031611,0.0002763281,0.00002806602,0.00008093771,0.001158571,0.0000252873,0.01036344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007921744,"threshold_uncertainty_score":0.02650094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03753900105095567,"score_gpt":0.3469511360635212,"score_spread":0.3094121350125656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}