{"id":"W4415444727","doi":"10.1158/1535-7163.targ-25-a042","title":"Abstract A042: Evolution of resistance in brain tumors: Effects of the blood brain barrier","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Blood–brain barrier; Drug; Pharmacokinetics; Drug resistance; Penetration (warfare); Population; Brain tumor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125401,0.0003095997,0.0003296052,0.0002510041,0.00017724,0.0006140996,0.0003538943,0.00066184,0.002468744],"category_scores_gemma":[0.000962965,0.0001311229,0.0006500844,0.0002254707,0.000271971,0.0004003179,0.0002966648,0.0005469728,0.0003138572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006604988,"about_ca_system_score_gemma":0.0004366352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002943843,"about_ca_topic_score_gemma":0.0008805165,"domain_scores_codex":[0.9998748,0.00003378571,0.000005629879,0.00002691942,0.00002828248,0.00003057879],"domain_scores_gemma":[0.9995143,0.0002277151,0.00009576138,0.00002565604,0.00009292326,0.00004349555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0004407865,0.0002646366,0.01052911,0.0002152898,0.0001110073,0.0004536121,0.00006705286,0.8538294,0.1190836,0.004745435,0.00136703,0.008892966],"study_design_scores_gemma":[0.00004015958,0.0005811621,0.005503085,0.00001194373,0.00004284915,0.0002575376,0.00003577601,0.9624545,0.02777848,0.001819634,0.00145126,0.00002361296],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979844,0.0005428591,0.0160006,0.0002786838,0.00002746102,0.0000303465,0.0003458022,0.00009420765,0.002836082],"genre_scores_gemma":[0.9964402,0.0001596176,0.001668188,0.00003426151,0.00000462268,0.00002486574,0.0001742256,0.00001894043,0.00147506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002943843,"threshold_uncertainty_score":0.00825876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008232857330306542,"score_gpt":0.2713940463445833,"score_spread":0.2631611890142767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}