{"id":"W4415444744","doi":"10.1158/1535-7163.targ-25-a085","title":"Abstract A085: OBP-004, a novel small-molecule dual inhibitor of CDK9/13, reduces bone, brain, lung and lymph node metastases in vivo, with highest potency on bone metastases","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Bioluminescence imaging; Lymph node; Prostate cancer; Bone marrow; Cancer; Breast cancer; Spleen; Metastatic breast cancer; Bone metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265775,0.0005100107,0.0003745147,0.0003161896,0.00009930535,0.0001945961,0.0003087996,0.0002983823,0.003723081],"category_scores_gemma":[0.00006427644,0.00012618,0.0002629789,0.0001911065,0.0001732505,0.0001641194,0.0001093458,0.0006502771,0.0005632473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961787,"about_ca_system_score_gemma":0.0004458207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111003,"about_ca_topic_score_gemma":0.001404463,"domain_scores_codex":[0.9999301,0.000009603057,0.000005042862,0.00001216385,0.00001739362,0.0000257116],"domain_scores_gemma":[0.9999605,0.000004726955,0.000008847974,0.000003092636,0.000004627417,0.0000181665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002570272,0.0007375437,0.0003043429,0.0001995248,0.0000291076,0.00007513527,0.00001041542,0.0002280268,0.9820024,0.0001348604,0.0009860408,0.01272236],"study_design_scores_gemma":[0.0009651096,0.01034886,0.005278962,0.00001175506,0.00007978085,0.0004518394,0.0000147627,0.0011378,0.9752759,0.00005111811,0.006374458,0.000009782924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885843,0.00300708,0.001953407,0.0002168569,0.0001038245,0.0001840771,0.001869742,0.0002763791,0.00380439],"genre_scores_gemma":[0.9817576,0.002006124,0.002609697,0.0001198365,0.00003284877,0.000209556,0.002962121,0.00003303412,0.01026921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003723081,"threshold_uncertainty_score":0.01245499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02277678333714673,"score_gpt":0.3126896407359538,"score_spread":0.2899128573988071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}