{"id":"W4415446229","doi":"10.1016/j.biopha.2025.118668","title":"Transcriptomic profiling of organoids derived from malignant effusions uncovers lncRNA MEG3 and target genes potentially involved in platinum resistance in serous ovarian carcinoma","year":2025,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Odense Universitetshospital; Syddansk Universitet; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Region Syddanmark","keywords":"Transcriptome; Epigenetics; Ovarian carcinoma; Carboplatin; Gene expression profiling; Downregulation and upregulation; Serous fluid; Organoid; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010749,0.0001513887,0.0002464043,0.0003125309,0.0001451552,0.0003304144,0.00008480223,0.0001504206,0.0005574455],"category_scores_gemma":[0.0001784887,0.00009930583,0.0002732977,0.0003112458,0.0001353259,0.0001360875,0.0002588933,0.0002033048,0.0001476117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143818,"about_ca_system_score_gemma":0.0001698212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006256966,"about_ca_topic_score_gemma":0.001492206,"domain_scores_codex":[0.9999248,0.000005792417,0.000007253709,0.00002523142,0.00002327367,0.00001364296],"domain_scores_gemma":[0.9999334,0.00001703033,0.00001847099,0.000007707054,0.00001288604,0.00001049487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252649,0.00001097732,0.01594532,0.0001029673,0.00002525157,0.0001738576,0.00009041659,0.0004557771,0.9782839,0.00004480216,0.0001408891,0.004473215],"study_design_scores_gemma":[0.00004707332,0.0005270489,0.4419134,0.0000448898,0.0002202298,0.00163232,0.0009072466,0.008455679,0.5335258,0.0003126534,0.01236658,0.00004705842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993373,0.001002637,0.002089412,0.00004273881,0.00001128265,0.00002305461,0.003016545,0.00005697436,0.0003843087],"genre_scores_gemma":[0.9898766,0.0007275967,0.00280444,0.00007929651,0.000005699502,0.00005592316,0.005787399,0.00002342566,0.0006397217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006256966,"threshold_uncertainty_score":0.001864851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009036417831185915,"score_gpt":0.2739543776178865,"score_spread":0.2649179597867006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}