{"id":"W4415448134","doi":"10.1016/j.jbc.2025.110854","title":"J-domain proteins cooperate with Hsp70 to drive multiphase separation of RNA-binding-deficient TDP-43","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Medical Research Council; Nanyang Technological University; Ministry of Education - Singapore; Duke-NUS Medical School","keywords":"Hsp70; Yeast; ATPase; Nucleus; Organism; Chaperone (clinical)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875203,0.0003413713,0.0002445091,0.0002225589,0.0001622582,0.0002592334,0.0002176936,0.0001780814,0.000531282],"category_scores_gemma":[0.0001463764,0.0001943069,0.0002355186,0.0001401772,0.0001765491,0.0001143758,0.0003438929,0.0003742269,0.0002811502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715459,"about_ca_system_score_gemma":0.0002478595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064627,"about_ca_topic_score_gemma":0.001541412,"domain_scores_codex":[0.9998623,0.00002176742,0.00001915332,0.0000237197,0.0000413997,0.00003161207],"domain_scores_gemma":[0.9997813,0.00004267775,0.00005024627,0.00002463151,0.00001717356,0.00008397215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004513403,0.0000154018,0.0001058101,0.00001141892,0.000002809941,0.00002613343,0.000006808757,0.00006794185,0.9993762,0.00003618237,0.00001491747,0.000291161],"study_design_scores_gemma":[0.000008684689,0.00005126966,0.002820894,0.000002490598,0.000006460477,0.0001011508,0.00001380833,0.001952208,0.9943084,0.00002405909,0.000708072,0.000002523408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962035,0.0004191769,0.002612659,0.00004498829,0.00001293603,0.00001839567,0.0001549212,0.00009395773,0.0004394395],"genre_scores_gemma":[0.9960609,0.0001895491,0.001764003,0.00002458227,0.000003096256,0.0000207266,0.0003285247,0.00004603224,0.001562553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064627,"threshold_uncertainty_score":0.002695739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761645530754254,"score_gpt":0.3218912098171248,"score_spread":0.3042747545095823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}