{"id":"W4415449915","doi":"10.1210/jendso/bvaf149.803","title":"SAT-248 A Case Series of Heterozygous Familial Hypercholesteremia With PCSK9 Inhibitor Failure","year":2025,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Evolocumab; Alirocumab; Ezetimibe; PCSK9; Familial hypercholesterolemia; Monoclonal; Statin; Dyslipidemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003796046,0.0001563241,0.0005441957,0.00004128127,0.0001215758,0.00001642154,0.0001452399,0.0000604136,0.000009009277],"category_scores_gemma":[0.00007186307,0.00008411172,0.0009521882,0.0002797396,0.0001489641,0.0001180893,0.00009599854,0.0005981479,6.898551e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001402563,"about_ca_system_score_gemma":0.0004583376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009815237,"about_ca_topic_score_gemma":0.0000582966,"domain_scores_codex":[0.9985883,0.00009068611,0.0004698079,0.0001246128,0.0005053389,0.0002212619],"domain_scores_gemma":[0.9988194,0.00003075879,0.0002664177,0.0004384187,0.000342253,0.0001027354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.0116761,0.003863951,0.2594483,0.01674414,0.02818579,0.03458243,0.02130083,0.000973779,0.1927989,0.001028452,0.2727507,0.1566466],"study_design_scores_gemma":[0.02960817,0.004345454,0.04542578,0.005207364,0.004263303,0.4963467,0.02197095,0.00006349076,0.183733,0.0003930147,0.2079681,0.0006746692],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992358,0.000962436,0.0001975005,0.005595388,0.0003618305,0.0003106046,0.000009715297,0.00001097642,0.0001936051],"genre_scores_gemma":[0.9939795,0.0001329802,0.003573639,0.0008900462,0.000640152,0.000004237234,8.592828e-7,0.00001749789,0.0007610767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4617643,"threshold_uncertainty_score":0.3429977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008194193182728052,"score_gpt":0.2508145392283521,"score_spread":0.2426203460456241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}