{"id":"W4415451869","doi":"10.37275/bsm.v10i1.1475","title":"A Neuroinflammatory Biomarker Profile Associated with Neuropathic Pain in Hansen's Disease: A Systematic Review and Meta-Analysis of S100B, TNF-α, and IL-6","year":2025,"lang":"","type":"review","venue":"Bioscientia Medicina Journal of Biomedicine and Translational Research","topic":"Leprosy Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biomarker; Neuropathic pain; Meta-analysis; Observational study; Pathophysiology; Confidence interval; Peripheral neuropathy; Peripheral; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.04691979,0.0008678687,0.009826288,0.008638139,0.0003071331,0.00009247882,0.0004623011,0.0003018819,0.0002899795],"category_scores_gemma":[0.01414156,0.0004784596,0.001138383,0.01042866,0.003120425,0.0002514565,0.0001592489,0.001674161,0.000001235763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157879,"about_ca_system_score_gemma":0.004534759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000511842,"about_ca_topic_score_gemma":0.00005593857,"domain_scores_codex":[0.9791455,0.009199955,0.003850537,0.00116304,0.005634254,0.001006754],"domain_scores_gemma":[0.9828162,0.01044084,0.00172941,0.0007115458,0.002648593,0.001653464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0006745057,0.0009992756,0.002434189,0.8668877,0.1169855,0.002694637,0.0003013841,3.28303e-7,0.00004949787,0.0000723928,0.0002391428,0.008661472],"study_design_scores_gemma":[0.003722701,0.003041213,0.01347509,0.2969496,0.6805723,0.0002706877,0.0001627613,0.0006924943,0.000002680638,0.00003861089,0.0007361269,0.0003357182],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009880775,0.9835293,0.0001754443,0.008455729,0.00006275398,0.006143011,0.0005894026,0.000006278754,0.00005004469],"genre_scores_gemma":[0.06353512,0.9351048,0.00006084427,0.0002462361,0.00004583473,0.0002183672,0.0002408388,0.00004581259,0.0005020981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5699381,"threshold_uncertainty_score":0.9997667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083670861610912,"score_gpt":0.3998034160995003,"score_spread":0.2914363299384091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}