{"id":"W4415451869","doi":"10.37275/bsm.v10i1.1475","title":"A Neuroinflammatory Biomarker Profile Associated with Neuropathic Pain in Hansen's Disease: A Systematic Review and Meta-Analysis of S100B, TNF-α, and IL-6","year":2025,"lang":"","type":"review","venue":"Bioscientia Medicina Journal of Biomedicine and Translational Research","topic":"Leprosy Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biomarker; Neuropathic pain; Meta-analysis; Observational study; Pathophysiology; Confidence interval; Peripheral neuropathy; Peripheral; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01209663,0.002409643,0.01651626,0.007604301,0.0007296215,0.003014594,0.002112797,0.002148164,0.002484962],"category_scores_gemma":[0.02580021,0.001474714,0.04009077,0.008336838,0.0007076575,0.001444239,0.001696838,0.001471584,0.0002423754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002077354,"about_ca_system_score_gemma":0.003874662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007053502,"about_ca_topic_score_gemma":0.01534998,"domain_scores_codex":[0.9913912,0.003792185,0.002732187,0.001028546,0.0007679068,0.0002879866],"domain_scores_gemma":[0.9806935,0.0139226,0.003116803,0.0006466783,0.001342375,0.000278148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00149102,0.00002421181,0.007408927,0.3048896,0.677833,0.0001445377,0.00008399641,0.0004257373,0.0002846743,0.00008854664,0.0003266013,0.006999048],"study_design_scores_gemma":[0.0002414422,0.0001199866,0.004370704,0.01463326,0.9794281,0.00009165703,0.00003696687,0.0001232197,0.00007425925,0.00009427945,0.0007689601,0.00001715706],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007799658,0.9904818,0.0004824663,0.0001581392,0.0001035112,0.0001820857,0.0006124332,0.0000183902,0.0001615632],"genre_scores_gemma":[0.2559268,0.7377012,0.002534883,0.0007975815,0.0002369035,0.001099524,0.001381889,0.0000334284,0.0002877843],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01651626,"threshold_uncertainty_score":0.06397384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083670861610912,"score_gpt":0.3998034160995003,"score_spread":0.2914363299384091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}