{"id":"W4415452621","doi":"10.5430/jst.v15n1p14","title":"Hypoxia-inducible factors: A target of cancer treatment","year":2025,"lang":"","type":"article","venue":"Journal of Solid Tumors","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Angiogenesis; Tumor microenvironment; Pathogenesis; Hypoxia (environmental); Transcription factor; Cancer; Signal transduction; Cancer cell; Protein subunit","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003208565,0.0004714036,0.001206954,0.0003456181,0.0001143285,0.00003425666,0.0004434436,0.000305782,0.0001939856],"category_scores_gemma":[0.0001360131,0.0003855684,0.0009001626,0.0003672186,0.0002097803,0.00001923926,0.0001161547,0.0002849571,0.000001998761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111417,"about_ca_system_score_gemma":0.002820082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000299817,"about_ca_topic_score_gemma":0.00007709203,"domain_scores_codex":[0.9971774,0.0001212617,0.001409326,0.0004002343,0.0003535012,0.0005383324],"domain_scores_gemma":[0.9971867,0.00003530941,0.001382102,0.0004957258,0.0006186896,0.0002814232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001212489,0.001507246,0.01520668,0.0003368942,0.003336539,0.00003059077,0.001021505,0.001636388,0.9351876,0.00008884547,0.0131172,0.02731797],"study_design_scores_gemma":[0.002532738,0.001098737,0.007520189,0.0004041283,0.0006034668,0.00003672859,0.0006613726,0.00002322151,0.706219,0.000149529,0.2804712,0.0002797431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8770887,0.1141038,0.0002955785,0.000427139,0.006354632,0.0002647646,0.0002838052,0.000003151804,0.001178395],"genre_scores_gemma":[0.9590551,0.03336516,0.0003317267,0.0001688087,0.003033028,0.00001109936,0.0000122219,0.00003691388,0.00398595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.267354,"threshold_uncertainty_score":0.9998596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440351547613534,"score_gpt":0.3000135359131595,"score_spread":0.2856100204370242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}