{"id":"W4415453464","doi":"10.1210/jendso/bvaf149.725","title":"SUN-777 CALIBRATE-PEDS: A Phase 2/3, Multicenter, Single-Arm, Open-Label Study Evaluating the Pharmacokinetics, Efficacy, and Safety of Encaleret in Pediatric Participants with Autosomal Dominant Hypocalcemia Type1","year":2025,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Dental and Craniofacial Research; Ultragenyx Pharmaceutical","keywords":"Hypoparathyroidism; Cohort; Adverse effect; Pharmacokinetics; Calcium; Dihydropyridine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001643594,0.001140816,0.001930447,0.0003342789,0.0003479396,0.001277125,0.0008805697,0.001123557,0.008199496],"category_scores_gemma":[0.001258694,0.000477056,0.001357523,0.0003330682,0.000791222,0.001214614,0.0002680749,0.003366262,0.001081127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008784655,"about_ca_system_score_gemma":0.001488308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007696098,"about_ca_topic_score_gemma":0.002013839,"domain_scores_codex":[0.9995616,0.0002028008,0.00001960407,0.00008928467,0.00006718979,0.00005939983],"domain_scores_gemma":[0.9993479,0.0001763282,0.0001422406,0.00005382887,0.00004618961,0.0002335559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7612158,0.03069266,0.003914628,0.002903535,0.003591292,0.0002142134,0.0002945331,0.001819968,0.02208652,0.0008242565,0.009885835,0.1625567],"study_design_scores_gemma":[0.7163941,0.2617643,0.008684043,0.0001584767,0.001127032,0.000429488,0.0001197402,0.002032147,0.003034138,0.0004399321,0.005767641,0.00004893412],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746261,0.01128097,0.001808924,0.001112338,0.0003965092,0.002986257,0.002807447,0.000420937,0.004560421],"genre_scores_gemma":[0.9789168,0.005105372,0.003730316,0.001765159,0.0002525799,0.002738116,0.002261498,0.0001049912,0.005125147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008199496,"threshold_uncertainty_score":0.02743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07121227904577873,"score_gpt":0.4144681974431673,"score_spread":0.3432559183973886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}