{"id":"W4415457043","doi":"10.3389/fcvm.2025.1655341","title":"Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Binghamton University; Health Sciences Centre Foundation","keywords":"Calcification; Oxidative phosphorylation; Aortic valve; Lipoprotein; Disease; Oxidative stress; Shear (geology); Calcinosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306839,0.0002988731,0.0002480997,0.0001621778,0.0001124024,0.0003116098,0.0003884821,0.0004139628,0.0009506779],"category_scores_gemma":[0.0002009925,0.0001926319,0.0002284065,0.00007344706,0.0001494477,0.0001239113,0.0002484846,0.0002955471,0.0002218054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162753,"about_ca_system_score_gemma":0.0002008283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002803644,"about_ca_topic_score_gemma":0.000610879,"domain_scores_codex":[0.999783,0.00002184656,0.00001453666,0.00006201833,0.00007894412,0.0000397732],"domain_scores_gemma":[0.9998521,0.0000447799,0.00002904168,0.00001714952,0.00002341782,0.00003354627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004575137,0.00004052133,0.0001728372,0.0000491195,0.000006430051,0.00004306416,0.00001216412,0.0003245782,0.9973436,0.00006563726,0.00007148011,0.001824831],"study_design_scores_gemma":[0.00002132792,0.000548711,0.003033482,0.000006870764,0.00002354751,0.0001592427,0.00001908824,0.008743497,0.9850861,0.00004145355,0.002300017,0.00001653709],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724196,0.001206912,0.02348097,0.0001228864,0.0001439999,0.0001145994,0.0004316731,0.0002621035,0.001817257],"genre_scores_gemma":[0.959344,0.0005663101,0.0369029,0.0001285344,0.00002698856,0.0001638675,0.0003871062,0.00001916932,0.002461181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009506779,"threshold_uncertainty_score":0.003180265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01574807674289873,"score_gpt":0.2928746724027529,"score_spread":0.2771265956598542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}