{"id":"W4415469100","doi":"10.1038/s41564-025-02146-w","title":"Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism","year":2025,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome British Columbia; Hudbay Minerals (Canada); University of British Columbia","funders":"Agence Nationale de la Recherche; Genome British Columbia; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Metaproteomics; Bacteria; Anaerobic exercise; Metabolic pathway; Metabolism; Glycine; Stable-isotope probing; Proteogenomics; Oxidative phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000245918,0.0004619602,0.0003725471,0.0006092835,0.0003006464,0.0007787548,0.0002850278,0.000474981,0.0005565581],"category_scores_gemma":[0.000333024,0.0002878327,0.0002576461,0.0005149659,0.0002933826,0.000353883,0.0006579176,0.0005520865,0.0002484759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162034,"about_ca_system_score_gemma":0.0002171072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755258,"about_ca_topic_score_gemma":0.001385903,"domain_scores_codex":[0.9998048,0.0000194783,0.0000112908,0.00005820146,0.00006230894,0.00004390868],"domain_scores_gemma":[0.999795,0.00004122034,0.00005422018,0.00002883677,0.00002723677,0.00005335947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001293659,0.00001482508,0.004313358,0.00001973472,0.00001033188,0.00003571636,0.00003236433,0.00005742646,0.993477,0.00007029129,0.00002439466,0.001815193],"study_design_scores_gemma":[0.00002422614,0.0004428144,0.3029593,0.00002662651,0.0001255523,0.001342791,0.0006260052,0.005182414,0.6853678,0.000955665,0.002916483,0.0000302634],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961201,0.0003926524,0.002224346,0.00007725305,0.000008853157,0.000007298754,0.0005899373,0.00005290106,0.0005265857],"genre_scores_gemma":[0.9976195,0.0002100488,0.00119166,0.00005028515,0.000006834317,0.000008226498,0.0005800653,0.00001695135,0.0003164769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007787548,"threshold_uncertainty_score":0.00186187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004526298633051535,"score_gpt":0.2279976111854451,"score_spread":0.2234713125523936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}