{"id":"W4415475889","doi":"10.1681/asn.2025da4gcc32","title":"Pegcetacoplan for 52 Weeks Results in Sustained Proteinuria Reduction to Remission (≤0.5 g/g) and Normalization (≤0.2 g/g): Phase 3 VALIANT Trial","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Normalization (sociology); Proteinuria; Reduction (mathematics); Kidney disease; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001390018,0.0009968142,0.001258662,0.0002010601,0.0004215588,0.0009725313,0.0005117069,0.001191461,0.003338785],"category_scores_gemma":[0.000689742,0.0003211523,0.001633189,0.0002409877,0.0005367136,0.0005153521,0.0002111982,0.002225744,0.0006826681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005498182,"about_ca_system_score_gemma":0.0009018118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005479225,"about_ca_topic_score_gemma":0.001211427,"domain_scores_codex":[0.9997458,0.0001060192,0.00001750659,0.00004262994,0.00002994218,0.00005807212],"domain_scores_gemma":[0.9995659,0.00008707806,0.0001190782,0.00004659579,0.00003163808,0.0001497348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8364978,0.01328662,0.003578364,0.001916737,0.002595314,0.0002449567,0.0002429524,0.001291233,0.02041639,0.0004322185,0.00985124,0.1096461],"study_design_scores_gemma":[0.8895063,0.09344329,0.01025508,0.0001091035,0.0004792411,0.0003392414,0.00004070305,0.0006532194,0.001858972,0.0002255195,0.003062922,0.00002631929],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855545,0.007407532,0.0004110426,0.0009903221,0.0002353592,0.001076858,0.0008501687,0.0001989836,0.003275263],"genre_scores_gemma":[0.9860678,0.004189143,0.001037904,0.002025555,0.0002447678,0.001433536,0.001450885,0.00003340056,0.003516999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003338785,"threshold_uncertainty_score":0.01116937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00916131810961886,"score_gpt":0.3065315849933032,"score_spread":0.2973702668836843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}