{"id":"W4415479617","doi":"10.1016/j.chembiol.2025.10.002","title":"Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression","year":2025,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Central China Normal University; University of Toronto","keywords":"Epigenetics; Leukemia; Gene; Endogeny; Methylation; Gene expression; Cell growth","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007882097,0.000174977,0.0002276811,0.00003248897,0.00003855389,0.000008658247,0.0003091744,0.0003284209,0.00004332917],"category_scores_gemma":[0.00006386513,0.0001435009,0.0001088533,0.00007659086,0.0002309597,0.000002701163,0.0001910686,0.0001203128,0.000007950827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000165682,"about_ca_system_score_gemma":0.00008341546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001773532,"about_ca_topic_score_gemma":0.000001283497,"domain_scores_codex":[0.9989539,0.00005734087,0.0002813241,0.0003890698,0.00004682409,0.0002715568],"domain_scores_gemma":[0.9994693,0.00003871408,0.000102821,0.000249498,0.00009428927,0.00004542463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123643,0.00007890137,0.004349424,0.00005113062,0.00004910868,4.534691e-7,0.00001655067,0.000001694031,0.9837531,0.00002840213,0.00885687,0.002690683],"study_design_scores_gemma":[0.0003457557,0.000207801,0.00008198439,0.00002664089,0.00002173409,7.866383e-7,0.00005943568,0.00001984437,0.9866512,0.0002857001,0.01215431,0.0001448148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884445,0.00812859,0.0004287508,0.00008647415,0.0001294475,0.0001187578,0.00002302208,0.00001533956,0.002625111],"genre_scores_gemma":[0.9979355,0.0004918276,0.0003504657,0.0003189623,0.00007125463,0.00002330496,0.0003775233,0.00001139992,0.0004197267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009491028,"threshold_uncertainty_score":0.5851797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006860153111046883,"score_gpt":0.2622952583307785,"score_spread":0.2554351052197316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}