{"id":"W4415491036","doi":"10.1142/s1793524525501359","title":"Dynamics modeling and synergistic mechanisms of oncolytic virus-bortezomib combination therapy","year":2025,"lang":"en","type":"article","venue":"International Journal of Biomathematics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"Natural Science Foundation of Zhejiang Province; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Oncolytic virus; Bortezomib; Combination therapy; Virotherapy; Population; Cancer; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005010481,0.0001065635,0.0001881721,0.000244294,0.00002906505,0.0000314524,0.0003624256,0.00008708013,0.000009775949],"category_scores_gemma":[0.0001563964,0.0000936111,0.00009632124,0.00009393896,0.00006329724,0.000009121141,0.00007678066,0.00007504332,6.364811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006008299,"about_ca_system_score_gemma":0.0001623236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005454473,"about_ca_topic_score_gemma":0.00002257713,"domain_scores_codex":[0.9988781,0.00004822402,0.000501858,0.0001053581,0.0003679382,0.00009857513],"domain_scores_gemma":[0.9987756,0.00004913014,0.0002996279,0.0001455415,0.0006893124,0.0000407728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001054515,0.0003588926,0.00004775344,0.00004281837,0.000596746,0.000008270827,0.00008774475,0.0009228922,0.9698662,0.0163387,0.00005916253,0.01061634],"study_design_scores_gemma":[0.002036278,0.001576572,0.00003246251,0.0002012062,0.00003723441,0.00004968682,0.0001810071,0.1705125,0.7499456,0.07525292,0.00004378024,0.0001306395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7700558,0.0004150697,0.2286798,0.000359925,0.0001985894,0.00008891538,0.0000147158,0.00000270649,0.0001844858],"genre_scores_gemma":[0.9959137,0.0007568555,0.00303436,0.00009675575,0.00005084752,0.000002759847,0.00001562351,0.0000131329,0.0001159727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2258579,"threshold_uncertainty_score":0.381735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754516830864053,"score_gpt":0.3318097537258339,"score_spread":0.3142645854171933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}