{"id":"W4415492295","doi":"10.1002/alz.70677","title":"Burden of psychiatric disease inversely correlates with Alzheimer's age at onset","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; National Institute on Aging","keywords":"Depression (economics); Anxiety; Psychiatric comorbidity; Age of onset; Psychiatric history; Retrospective cohort study; Comorbidity; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002952551,0.0002090156,0.0002307491,0.0008041606,0.0003023496,0.0004343646,0.0001708329,0.0001942426,0.00274522],"category_scores_gemma":[0.00200872,0.0001600976,0.0002248342,0.0005500336,0.0001589712,0.0001922077,0.0002325431,0.0003367113,0.0002834933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002822083,"about_ca_system_score_gemma":0.0002449655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007270284,"about_ca_topic_score_gemma":0.008677491,"domain_scores_codex":[0.9998125,0.00003041744,0.00002796004,0.00005263739,0.00004457936,0.00003180145],"domain_scores_gemma":[0.9974028,0.0002979521,0.001491081,0.0001053911,0.0003286428,0.0003740019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004034672,0.000007937712,0.9987406,0.000007078014,0.00002250214,0.00002668434,0.0000121574,0.0000120155,0.0001261545,0.000003909772,0.00007104453,0.0009295742],"study_design_scores_gemma":[6.900714e-7,0.00001397135,0.9997361,0.000003031971,0.000009331204,0.0001239263,0.00001401892,0.00002177048,0.00002096604,0.000004485041,0.00005105421,5.723861e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970292,0.001000541,0.00006721826,0.00006363659,0.000009662464,0.000007149824,0.0006818696,0.000008486206,0.001132184],"genre_scores_gemma":[0.9990807,0.0002554304,0.00007566929,0.00001520257,0.00001716366,0.000002929879,0.0003609259,0.00000109719,0.0001909178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007270284,"threshold_uncertainty_score":0.01445591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946231500570283,"score_gpt":0.2948971589860626,"score_spread":0.2754348439803598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}