{"id":"W4415506920","doi":"10.1139/jpn-25-0017","title":"Differential DNA methylation and gene expression in stem cell-derived cardiomyocytes from patients with and without a history of clozapine-induced myocarditis","year":2025,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; Mathison Centre for Mental Health Research and Education; Alberta Innovates","keywords":"Clozapine; DNA methylation; Epigenetics; Gene expression; Myocarditis; Gene; Methylation; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007740624,0.0001403998,0.0001986401,0.0004573515,0.0001378201,0.0002079759,0.00007287761,0.0001941859,0.001026946],"category_scores_gemma":[0.0002529021,0.0001047731,0.0001592418,0.0002236367,0.0001391788,0.00005927606,0.0001175793,0.0001714517,0.0001333974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001039973,"about_ca_system_score_gemma":0.00006594288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009344424,"about_ca_topic_score_gemma":0.001576518,"domain_scores_codex":[0.9999053,0.00001017203,0.000009469651,0.00004000034,0.00002022546,0.00001473724],"domain_scores_gemma":[0.9999233,0.00001319971,0.00002747804,0.000006040709,0.00001349733,0.00001635493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002412545,0.0000693488,0.393488,0.0001390046,0.0002638845,0.002275664,0.001161907,0.0002012223,0.5805417,0.00009534469,0.0003113625,0.01904002],"study_design_scores_gemma":[0.00003502379,0.0003303416,0.9667245,0.00001558306,0.0001423631,0.00342319,0.000491036,0.0004626402,0.02715845,0.000128604,0.0010747,0.00001339869],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987195,0.0003336305,0.0002588369,0.00002121713,0.00000484753,0.000005806971,0.0003974336,0.000005703306,0.0002530827],"genre_scores_gemma":[0.9986395,0.0002146687,0.000238075,0.0000328711,0.000005409874,0.000009986769,0.0005731346,0.000004798161,0.0002815856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026946,"threshold_uncertainty_score":0.003435493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00935049877541863,"score_gpt":0.2295690518644974,"score_spread":0.2202185530890788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}