{"id":"W4415517694","doi":"10.1038/s41467-025-64477-w","title":"Akkermansia muciniphila MucT harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Symrise; Stiftelsen Siamon; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Soehngen Institute of Anaerobic Microbiology","keywords":"Akkermansia muciniphila; Siderophore; Lipocalin; Ferrous; Transcriptome; Polyphenol; Ferritin; Metabolic pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447585,0.0006061277,0.0004216921,0.0002458308,0.0002902209,0.0006450874,0.0001784189,0.0005002503,0.0005645994],"category_scores_gemma":[0.0001614069,0.0001306163,0.0003991853,0.000173333,0.0002024371,0.0005097619,0.0005980694,0.0006976616,0.0002474307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483468,"about_ca_system_score_gemma":0.0002245405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007896029,"about_ca_topic_score_gemma":0.001112872,"domain_scores_codex":[0.9998556,0.00001808174,0.000009948349,0.00003349793,0.00003667799,0.00004620902],"domain_scores_gemma":[0.9999043,0.00001153005,0.00002774111,0.00001012287,0.00001431269,0.00003201999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002472941,0.00001139878,0.0002123346,0.00004963935,0.000003198434,0.00006616469,0.00002037721,0.00002411174,0.9987057,0.0000407947,0.00002853513,0.0008129046],"study_design_scores_gemma":[0.00002641434,0.0008148866,0.03160157,0.00006610525,0.00007195694,0.0009362941,0.0004597091,0.002916264,0.9495186,0.0003591762,0.0131822,0.00004683042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992704,0.001880607,0.002313818,0.0003336849,0.00005033062,0.00003561645,0.0005356367,0.0001798925,0.001966504],"genre_scores_gemma":[0.9933392,0.0007502841,0.003040783,0.0001920847,0.00001868409,0.00003936568,0.0005442218,0.00003282289,0.002042458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007896029,"threshold_uncertainty_score":0.001888812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389047633535925,"score_gpt":0.3210649848913239,"score_spread":0.3071745085559646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}