{"id":"W4415520288","doi":"10.1016/j.jtho.2025.09.1118","title":"PT1.03.06 Mechanisms of Acquired Resistance to First-Line Amivantamab Plus Lazertinib Vs Osimertinib: Updated Analysis from MARIPOSA","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Acquired resistance; Osimertinib; Tyrosine-kinase inhibitor; Tyrosine kinase; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002103239,0.0005464887,0.001354082,0.001383599,0.0002210915,0.001704806,0.0008477878,0.0004515366,0.00670771],"category_scores_gemma":[0.002978169,0.0003575743,0.003193643,0.001914083,0.0002391743,0.00111725,0.0006942321,0.001362203,0.001258569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001292369,"about_ca_system_score_gemma":0.00120188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00207709,"about_ca_topic_score_gemma":0.006132411,"domain_scores_codex":[0.9993045,0.0001334941,0.00008336515,0.0001422094,0.0002326133,0.0001037581],"domain_scores_gemma":[0.9979717,0.0006587878,0.000682983,0.0001683509,0.0003314364,0.0001866992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0230575,0.0002714896,0.2226946,0.004816446,0.01343688,0.0004136328,0.0001718808,0.002247861,0.006176137,0.001345507,0.04581559,0.6795525],"study_design_scores_gemma":[0.004993808,0.00323297,0.7571687,0.003439163,0.03474607,0.003190997,0.0002653966,0.002634966,0.003591164,0.002493298,0.1840871,0.000156386],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5497948,0.3528048,0.002910789,0.008897802,0.001095363,0.000530901,0.05181878,0.0003764749,0.03177032],"genre_scores_gemma":[0.8384542,0.1016376,0.005125983,0.004849751,0.001270063,0.0004094735,0.04013664,0.0002539944,0.007862146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00670771,"threshold_uncertainty_score":0.02243948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603699220053034,"score_gpt":0.4069026209748416,"score_spread":0.3908656287743113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}