{"id":"W4415525502","doi":"10.1126/sciadv.adu1985","title":"Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Retinal Imaging and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; University of Toronto; Hamilton Health Sciences; Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Fight for Sight UK; Medical Research Council; Diabetes UK; British Heart Foundation","keywords":"Mendelian randomization; Biobank; Disease; Confounding; Diabetes mellitus; Longevity; Epidemiology; Genome-wide association study; Mendelian inheritance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01168741,0.0005890226,0.0008792823,0.001086175,0.0005704209,0.0007127342,0.000594786,0.0006349628,0.002742135],"category_scores_gemma":[0.02266317,0.0002426404,0.0009180051,0.001237354,0.0009617218,0.0003809847,0.0004988404,0.0006474819,0.0001451469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004290522,"about_ca_system_score_gemma":0.0007478245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004426694,"about_ca_topic_score_gemma":0.002818237,"domain_scores_codex":[0.9865621,0.008780741,0.0005851798,0.002321277,0.001377387,0.000373311],"domain_scores_gemma":[0.9883937,0.006255305,0.002150449,0.002605003,0.000316451,0.00027905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008863459,0.0003220054,0.9195491,0.0001747357,0.00586908,0.001923867,0.0004952915,0.001786596,0.007307198,0.01207526,0.002673344,0.03896005],"study_design_scores_gemma":[0.001633393,0.00266026,0.9332772,0.00009051248,0.003779547,0.00551276,0.0002562866,0.02793962,0.002609829,0.01673385,0.005412195,0.00009452206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641962,0.001408773,0.03064108,0.0006043275,0.0001390637,0.0001832541,0.0007365193,0.0002045993,0.00188622],"genre_scores_gemma":[0.993825,0.0001610977,0.005256694,0.0001472213,0.00003843162,0.00008900902,0.0001668655,0.00001888582,0.0002969521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01168741,"threshold_uncertainty_score":0.06180966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005823677046485242,"score_gpt":0.2966940231046442,"score_spread":0.290870346058159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}