{"id":"W4415525558","doi":"10.1126/sciadv.adx3794","title":"The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Novo Nordisk; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Leiden","keywords":"Hyperlipidemia; Cytokine; Apolipoprotein B; Inflammation; Lipoprotein; Cholesterol; Lipogenesis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002663011,0.0005612639,0.000516227,0.0007018262,0.0002094401,0.0003725617,0.0003181327,0.000773898,0.001360307],"category_scores_gemma":[0.0001689101,0.00018266,0.0002820905,0.0002638771,0.0004020007,0.0002390647,0.0001514863,0.001152474,0.000382009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000354295,"about_ca_system_score_gemma":0.0004512397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099704,"about_ca_topic_score_gemma":0.001730087,"domain_scores_codex":[0.9997229,0.0000468251,0.00002514802,0.00004290062,0.00007099163,0.00009114601],"domain_scores_gemma":[0.9997683,0.00002444776,0.0000742061,0.00002102879,0.00003340549,0.00007859171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006818932,0.0001210246,0.0001532019,0.00005086774,0.00001517071,0.0000551903,0.00001992967,0.0001350783,0.9945908,0.0002118051,0.0001864877,0.003778599],"study_design_scores_gemma":[0.000247985,0.001912375,0.002631034,0.00002967303,0.00009098739,0.0002628089,0.00003889677,0.001584883,0.9868549,0.0001101792,0.006222537,0.00001379688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848334,0.004401747,0.004999643,0.0005619253,0.000159186,0.00006842636,0.000763641,0.0004768125,0.003735272],"genre_scores_gemma":[0.9864953,0.003180774,0.004588678,0.0003601992,0.00009346096,0.0001275522,0.0008949575,0.0000975295,0.004161638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360307,"threshold_uncertainty_score":0.004550636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006561242025815111,"score_gpt":0.2594539225990886,"score_spread":0.2528926805732735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}