{"id":"W4415532920","doi":"10.70962/jhi.20250149","title":"The seven enigmas of SARS-CoV-2: From the past to the future","year":2025,"lang":"en","type":"article","venue":"Journal of Human Immunity","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Institute of Infection and Immunity; Hospital for Sick Children; University Hospital Foundation","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Staatssekretariat für Bildung, Forschung und Innovation; Takeda Canada; National Institutes of Health; Canadian Institutes of Health Research; European Academy of Dermatology and Venereology; NHLBI Division of Intramural Research; Public Health Agency; Novo Nordisk; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; European Commission; Merck Canada; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Boettcher Foundation; Institut National de la Santé et de la Recherche Médicale; Pfizer; Moderna; Fondation du Souffle; Stavros Niarchos Foundation; CSL Behring; Institut des maladies génétiques Imagine; Amgen; St. Giles Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Howard Hughes Medical Institute; Fondation pour la Recherche Médicale; Cancer Research Institute; Public Health Agency of Canada; National Science Foundation","keywords":"Pandemic; Disease; Pneumonia; Immunity; Coronavirus disease 2019 (COVID-19); Human genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001987306,0.0001369724,0.000326211,0.000103513,0.0007347608,0.00008361349,0.001183176,0.00008125089,0.00001503645],"category_scores_gemma":[0.0003651323,0.00005753897,0.0002811314,0.0003641974,0.0002149648,0.00006350836,0.0002647738,0.00134506,0.00001436136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020149,"about_ca_system_score_gemma":0.000352369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007797973,"about_ca_topic_score_gemma":0.001018478,"domain_scores_codex":[0.9980585,0.0004727667,0.0005359061,0.00009031049,0.0005986891,0.0002438032],"domain_scores_gemma":[0.997539,0.0008502778,0.0002588047,0.0008770801,0.0004523556,0.00002241423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002105077,0.0005100305,0.0509985,0.00007433778,0.001304722,0.00007155766,0.01027038,0.000001405279,0.7249307,0.001571289,0.1833317,0.02483033],"study_design_scores_gemma":[0.001279279,0.0004481783,0.163574,0.0002337533,0.0001639353,0.00003743726,0.006457142,0.00000680157,0.1018386,0.001681704,0.7242018,0.00007734705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728985,0.002852308,0.00003473414,0.02052232,0.0004132804,0.000271315,0.000008320178,0.000007093601,0.002992152],"genre_scores_gemma":[0.9715242,0.00004130888,0.00002728747,0.02721823,0.00100477,0.000005584305,8.821596e-7,0.00001278587,0.0001649656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6230921,"threshold_uncertainty_score":0.5843692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04299708597233187,"score_gpt":0.3723732057483151,"score_spread":0.3293761197759832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}