{"id":"W4415532920","doi":"10.70962/jhi.20250149","title":"The seven enigmas of SARS-CoV-2: From the past to the future","year":2025,"lang":"en","type":"article","venue":"Journal of Human Immunity","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Institute of Infection and Immunity; Hospital for Sick Children; University Hospital Foundation","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Staatssekretariat für Bildung, Forschung und Innovation; Takeda Canada; National Institutes of Health; Canadian Institutes of Health Research; European Academy of Dermatology and Venereology; NHLBI Division of Intramural Research; Public Health Agency; Novo Nordisk; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; European Commission; Merck Canada; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Boettcher Foundation; Institut National de la Santé et de la Recherche Médicale; Pfizer; Moderna; Fondation du Souffle; Stavros Niarchos Foundation; CSL Behring; Institut des maladies génétiques Imagine; Amgen; St. Giles Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Howard Hughes Medical Institute; Fondation pour la Recherche Médicale; Cancer Research Institute; Public Health Agency of Canada; National Science Foundation","keywords":"Pandemic; Disease; Pneumonia; Immunity; Coronavirus disease 2019 (COVID-19); Human genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006000918,0.0008462782,0.001817071,0.002107517,0.002415485,0.004689461,0.001341764,0.005291906,0.003254704],"category_scores_gemma":[0.005378524,0.0004676362,0.0007762545,0.001596647,0.009407243,0.01505553,0.003260949,0.01122962,0.00135946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002624446,"about_ca_system_score_gemma":0.004926728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00190102,"about_ca_topic_score_gemma":0.003648439,"domain_scores_codex":[0.9985813,0.0004737157,0.0001709167,0.0002281125,0.0002768242,0.0002691542],"domain_scores_gemma":[0.9955701,0.001770798,0.000360682,0.0004123041,0.0007556629,0.00113044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001057887,0.0003575195,0.01148148,0.005125041,0.0002562031,0.002779694,0.00566669,0.001109566,0.006120417,0.1793356,0.2180733,0.5686367],"study_design_scores_gemma":[0.00005133906,0.0002279351,0.004828784,0.003575059,0.00009169597,0.003359623,0.009988512,0.0006015743,0.0006297477,0.2415628,0.7349509,0.0001320734],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004951842,0.7227975,0.001893664,0.2618284,0.004946978,0.0000138519,0.0001534517,0.00009919763,0.003315099],"genre_scores_gemma":[0.06295212,0.8407698,0.005316826,0.06904707,0.01835478,0.00007984477,0.000320106,0.00005741972,0.003102027],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006000918,"threshold_uncertainty_score":0.03173625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04299708597233187,"score_gpt":0.3723732057483151,"score_spread":0.3293761197759832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}