{"id":"W4415534276","doi":"10.1101/2025.10.23.684261","title":"Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Hyundai Hope On Wheels; Albert and Bettie Sacchi Foundation","keywords":"Chimeric antigen receptor; Leukemia; CD19; CAR T-cell therapy; T cell; Bone marrow; PI3K/AKT/mTOR pathway; Cell therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002095873,0.00008866295,0.0002398853,0.0001968797,0.0001065497,0.0002836334,0.00009252104,0.0002438445,0.0007761724],"category_scores_gemma":[0.0003004771,0.00006197457,0.00009739121,0.0001697576,0.0001212997,0.0001617101,0.0001778676,0.0002797417,0.0002034638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746151,"about_ca_system_score_gemma":0.00008330636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001902542,"about_ca_topic_score_gemma":0.0002195182,"domain_scores_codex":[0.9998993,0.00002813741,0.00000848479,0.00001877168,0.00001671761,0.00002863295],"domain_scores_gemma":[0.9998343,0.00003169928,0.00005765988,0.00001234634,0.00001243142,0.00005154825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01216872,0.0004507602,0.2773944,0.00006001248,0.00007196664,0.0008833764,0.0002825093,0.0007950275,0.6781292,0.0001368117,0.0002147966,0.0294125],"study_design_scores_gemma":[0.0001283604,0.006087391,0.9129138,0.000008647806,0.0000963488,0.00193527,0.0002944272,0.001768251,0.07531986,0.0001811412,0.001250325,0.00001626443],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994625,0.0002042889,0.00009952867,0.00001973861,0.000001383229,0.00000372329,0.0000455698,0.000004588389,0.0001585891],"genre_scores_gemma":[0.9995778,0.00006515651,0.00008268301,0.00001993523,0.000003645575,0.000006033567,0.0001240653,0.000002749186,0.0001178391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007761724,"threshold_uncertainty_score":0.002596557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02008847682474215,"score_gpt":0.27924940910928,"score_spread":0.2591609322845379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}