{"id":"W4415543535","doi":"10.1111/hae.70113","title":"The WFH Guidelines for the Management of Haemophilia: AAV Gene Therapy, 2025","year":2025,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; McMaster University; Impact; University of Toronto; SickKids Foundation; Hospital for Sick Children; Canadian Hemophilia Society","funders":"Spark Therapeutics; Voyager Therapeutics; Swedish Orphan Biovitrum; CSL Behring; St. Jude Children's Research Hospital; Regeneron Pharmaceuticals; Novo Nordisk; Sanofi; Chugai Pharmaceutical; Pfizer","keywords":"Haemophilia; Clinical trial; Health care; MEDLINE; Guideline; Stakeholder; Genetic enhancement","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007461057,0.001125165,0.001169472,0.005439352,0.0008491465,0.003685886,0.003037738,0.00731102,0.01709391],"category_scores_gemma":[0.0201976,0.0006748484,0.001704035,0.002774919,0.001697011,0.002137794,0.001927025,0.006589303,0.01891685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003058477,"about_ca_system_score_gemma":0.01184039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01491089,"about_ca_topic_score_gemma":0.02061905,"domain_scores_codex":[0.9906645,0.0027278,0.001753904,0.0002754098,0.004070924,0.0005076191],"domain_scores_gemma":[0.9888587,0.002759741,0.001445889,0.0003531776,0.005921651,0.0006607688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003013054,0.00005932543,0.0002197409,0.0008185226,0.00001264113,0.0001704634,0.00009938807,0.0001980674,0.0002942147,0.004030532,0.8645468,0.1295202],"study_design_scores_gemma":[0.00002133307,0.00002710271,0.0005104047,0.002405221,0.00001565787,0.0004931141,0.00003524747,0.0001011105,0.0001125529,0.00160273,0.9946622,0.00001335136],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.00208525,0.352446,0.02841001,0.2998003,0.03768446,0.002704177,0.01431959,0.002567494,0.2599827],"genre_scores_gemma":[0.01376703,0.4081517,0.09458587,0.1725612,0.01478608,0.005884127,0.04340221,0.001114244,0.2457475],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01709391,"threshold_uncertainty_score":0.05718488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1204648777859663,"score_gpt":0.4146776296007526,"score_spread":0.2942127518147863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}