{"id":"W4415544009","doi":"10.1016/j.ard.2025.09.015","title":"Autoreactive T cells identified in patients with anti-Jo1+ antisynthetase syndrome recognise a new epitope on histidyl t-RNA synthetase","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Stiftelsen Professor Nanna Svartz Fond; Alex och Eva Wallströms Stiftelse för Vetenskaplig Forskning och Utbildning; Uppsala Universitet; Akademiska Sjukhuset; Science for Life Laboratory; Vetenskapsrådet; National Health and Medical Research Council; Reumatikerförbundet; Knut och Alice Wallenbergs Stiftelse; Uppsala Multidisciplinary Center for Advanced Computational Science; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Stiftelsen Konung Gustaf V:s 80-årsfond; Karolinska Institutet; Myositis Association; Hjärt-Lungfonden; Åke Wiberg Stiftelse","keywords":"Epitope; Antisynthetase syndrome; T-cell receptor; T cell; Antigen; T lymphocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097861,0.0003370773,0.0002142529,0.0002833158,0.0001383567,0.000217705,0.0001206224,0.000418664,0.002228562],"category_scores_gemma":[0.0002824676,0.0001072291,0.0001571353,0.0001826691,0.0001811253,0.000125653,0.0001225717,0.0002285385,0.0003270578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007554565,"about_ca_system_score_gemma":0.0000424448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000218449,"about_ca_topic_score_gemma":0.0001712365,"domain_scores_codex":[0.9998754,0.00001969111,0.0000154134,0.00004302527,0.00002021737,0.00002617802],"domain_scores_gemma":[0.9998294,0.000073945,0.00004230444,0.00001056177,0.0000157544,0.00002795603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001004194,0.0001371147,0.1774808,0.0001569202,0.00004657079,0.01208576,0.0004372685,0.0002315819,0.7935858,0.0000834952,0.0002253596,0.01452507],"study_design_scores_gemma":[0.0001630859,0.002643948,0.7825755,0.00004304647,0.0001481072,0.1204605,0.0007523769,0.001877636,0.08747222,0.0002301411,0.003614079,0.00001942785],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991103,0.0001967831,0.0002782079,0.00001554109,0.000003852609,0.00000591906,0.00003374617,0.00001404301,0.0003417372],"genre_scores_gemma":[0.9993194,0.00009144802,0.000274853,0.00003482942,0.00001367106,0.00000541296,0.00006445633,0.00000297032,0.0001929314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002228562,"threshold_uncertainty_score":0.007455289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060103154316689,"score_gpt":0.251053295990568,"score_spread":0.2404522644474011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}