{"id":"W4415552474","doi":"10.1101/2025.10.23.684176","title":"Loss of cell cycle gatekeeping by CNOT3 impairs hematopoietic stem and progenitor cell division and repopulating activity","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Occupational Cancer Research Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Haematopoiesis; Stem cell; Progenitor cell; Hematopoietic stem cell; Conditional gene knockout; Transcriptome; Gene expression profiling; Cell cycle; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285466,0.0003894327,0.0002672175,0.0003191294,0.0001972068,0.0003266372,0.0002998135,0.0003584775,0.00302507],"category_scores_gemma":[0.00009394708,0.0001402566,0.0003115997,0.000213667,0.0003872614,0.0001729339,0.0002341642,0.0007249757,0.0006597821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429871,"about_ca_system_score_gemma":0.0003549513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356354,"about_ca_topic_score_gemma":0.001997417,"domain_scores_codex":[0.9998103,0.00001577774,0.00002195726,0.00004073929,0.00006421305,0.00004705684],"domain_scores_gemma":[0.9998067,0.00002471727,0.00006075681,0.00002223012,0.00001253267,0.00007307099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008189049,0.00001296346,0.00008316715,0.00001480239,0.000002385645,0.00003422502,0.000005489786,0.00004550526,0.9991326,0.00009390913,0.00004322694,0.0004498225],"study_design_scores_gemma":[0.0000203507,0.00009891669,0.004739259,0.000005451855,0.0000103918,0.0001765029,0.00002580067,0.001258275,0.9911681,0.00007967273,0.002412045,0.00000519699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989599,0.0007639545,0.004545911,0.0001602021,0.00008253439,0.00003967652,0.002669015,0.0002737056,0.00186606],"genre_scores_gemma":[0.9905012,0.0003772244,0.002233973,0.00008531717,0.000009844404,0.00003998751,0.001881517,0.0001146695,0.004756371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00302507,"threshold_uncertainty_score":0.01011992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079928948092345,"score_gpt":0.2314596104930844,"score_spread":0.220660321012161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}