{"id":"W4415559688","doi":"10.1101/2025.10.25.684461","title":"Loss of Complement Factor D suppresses alternative pathway activation but fails to reduce lipofuscin accumulation in the retinal pigmented epithelium of <i> Abca4 <sup>-/-</sup> </i> mice","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"ABCA4; Alternative complement pathway; Lipofuscin; Stargardt disease; Retinal pigment epithelium; Classical complement pathway; Complement system; Retinal degeneration","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002997209,0.000950288,0.0005117889,0.0009615719,0.0003006298,0.0005948713,0.0005507056,0.001086805,0.001870152],"category_scores_gemma":[0.0002835187,0.0004320492,0.0005389623,0.0002597482,0.0007698859,0.0003692357,0.0003483944,0.001479227,0.0007236259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007211366,"about_ca_system_score_gemma":0.0004011172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002254519,"about_ca_topic_score_gemma":0.002188966,"domain_scores_codex":[0.9994515,0.00008216542,0.00009617689,0.0001186828,0.0001322212,0.0001193154],"domain_scores_gemma":[0.9991527,0.0001170464,0.0002652607,0.00008829236,0.000070319,0.0003065193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002156558,0.00006153702,0.0001265386,0.00002186719,0.000007701998,0.00005656505,0.00001410201,0.00003888642,0.998979,0.0001010723,0.00003334659,0.0003437786],"study_design_scores_gemma":[0.00007291217,0.0005128934,0.003471102,0.00001046745,0.00002529538,0.0003357237,0.00004612133,0.001055697,0.9930158,0.00006695323,0.001377776,0.000009283605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937448,0.0008030615,0.002168806,0.0003153058,0.00004726054,0.0000595686,0.001294128,0.0002496502,0.001317475],"genre_scores_gemma":[0.9899093,0.0004842628,0.003046298,0.0001922783,0.00001963227,0.0001040799,0.0009761511,0.0001688013,0.005099223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002254519,"threshold_uncertainty_score":0.006256282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251814275023413,"score_gpt":0.2664745980910572,"score_spread":0.2439564553408231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}