{"id":"W4415564942","doi":"10.3390/cells14211669","title":"Caspase-6 Is a Non-Apoptotic Effector of Shear-Induced Morphological Adaptation in Pulmonary Artery Endothelial Cells In Vitro","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Fondation Leducq; Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Mechanosensitive channels; Endothelial stem cell; Endothelium; Mechanotransduction; Effector; Caspase; Shear stress; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003278796,0.0001485435,0.0002441251,0.0001909321,0.00002031816,0.00001065006,0.0001972754,0.0002585443,0.00004928913],"category_scores_gemma":[0.00006719802,0.000144391,0.00008173886,0.0002628171,0.00005798418,0.000004133372,0.0001253166,0.0002185549,0.00004138917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005202464,"about_ca_system_score_gemma":0.0001721322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002656384,"about_ca_topic_score_gemma":0.00002353113,"domain_scores_codex":[0.9986017,0.0001950703,0.0003110462,0.0003988633,0.0001548144,0.0003384817],"domain_scores_gemma":[0.9994618,0.00006134995,0.00003810468,0.0003322753,0.00004514095,0.00006133743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000401954,0.0002113781,0.0002057885,0.00008975744,0.00001101371,0.0001104822,0.00006692098,0.0001082423,0.9954909,9.480715e-7,0.0001594295,0.003143149],"study_design_scores_gemma":[0.0007666156,0.0002067119,0.001691894,0.00004484506,0.000004155102,0.000004939342,0.00005723699,0.002157804,0.994665,0.00001783904,0.0002652909,0.0001176935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997568,0.00008782162,0.0003946389,0.00008023842,0.0001180656,0.0006431477,0.0000560029,0.000004755719,0.001047319],"genre_scores_gemma":[0.9987331,0.00004027867,0.0004440208,0.0001345237,0.00005067115,0.00008478094,0.00003976599,0.00001420758,0.0004586642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003025456,"threshold_uncertainty_score":0.5888094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509464382145522,"score_gpt":0.2729401072598914,"score_spread":0.2578454634384362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}