{"id":"W4415569423","doi":"10.1016/j.jtha.2025.09.041","title":"A comprehensive care pathway of gene therapy for hemophilia based on current guideline documents and summary of product characteristics: communication from the ISTH SSC working group on gene therapy","year":2025,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society; Queen's University","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Guideline; Genetic enhancement; Care pathway; Product (mathematics); Health care; MEDLINE; Critical pathways","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01400053,0.0007094544,0.0006008963,0.006117749,0.001103502,0.003421744,0.001321651,0.00261961,0.01294696],"category_scores_gemma":[0.02821836,0.0003652349,0.001278924,0.005345504,0.000581039,0.004064029,0.002818269,0.002297542,0.005964571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003942869,"about_ca_system_score_gemma":0.02753915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008844157,"about_ca_topic_score_gemma":0.01312175,"domain_scores_codex":[0.9906776,0.004197855,0.002194901,0.0003536546,0.002175997,0.0004001197],"domain_scores_gemma":[0.9808403,0.00719257,0.002690276,0.0007086843,0.007387777,0.001180302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001317992,0.0001690875,0.003044284,0.009224248,0.00008007509,0.0009531582,0.003883317,0.0005699222,0.001628538,0.007075584,0.4914407,0.4817993],"study_design_scores_gemma":[0.00009621945,0.000104755,0.004486867,0.009995531,0.0001117043,0.0008298991,0.002170221,0.0004580949,0.001094527,0.002964905,0.9776164,0.00007085331],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.04156325,0.1336695,0.09016874,0.4184381,0.006018174,0.01392059,0.03068446,0.004386904,0.2611503],"genre_scores_gemma":[0.1814053,0.2458058,0.4399393,0.04025672,0.002143768,0.01099195,0.03680337,0.001093507,0.04156027],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01400053,"threshold_uncertainty_score":0.0740428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.092259960491892,"score_gpt":0.3785282787223471,"score_spread":0.2862683182304551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}