{"id":"W4415583163","doi":"10.1101/2025.10.23.684149","title":"Acute PFOS exposure consistently dysregulates glucose-stimulated insulin secretion across model systems","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Carleton University","funders":"Canadian Institutes of Health Research; Diabetes Canada","keywords":"Pancreas; Perfluorooctane; Endocrine system; Diabetes mellitus; Islet; Secretion; Pancreatic islets; Homeostasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022525,0.0005541193,0.0003249696,0.0002593323,0.0002044792,0.0004543616,0.0002311809,0.0002889305,0.001237818],"category_scores_gemma":[0.0001674799,0.0001405426,0.0004843451,0.0002364582,0.000365562,0.000259267,0.0003235164,0.0006784772,0.0002467885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004699691,"about_ca_system_score_gemma":0.0002850515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022247,"about_ca_topic_score_gemma":0.001367662,"domain_scores_codex":[0.999665,0.00004649489,0.00003168455,0.00009499378,0.00008957802,0.00007219872],"domain_scores_gemma":[0.9998677,0.00002209546,0.00005339934,0.00001947507,0.00002031377,0.00001711012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003671333,0.00006177188,0.001593583,0.00007721721,0.00001714375,0.0001032611,0.0000235507,0.0001469812,0.9956172,0.00003568188,0.00006481724,0.001891863],"study_design_scores_gemma":[0.00001380666,0.001620311,0.01045695,0.00001389989,0.00004643322,0.0002112524,0.000100571,0.0004455262,0.9854365,0.00005883977,0.001588124,0.000007717385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888669,0.002841848,0.005617808,0.000184433,0.0001148248,0.00007690219,0.0006642968,0.0001117227,0.001521428],"genre_scores_gemma":[0.9906954,0.002825128,0.00348612,0.0001960868,0.00003403327,0.0001299494,0.0008264337,0.00002129922,0.001785575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237818,"threshold_uncertainty_score":0.004140913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008292256819288678,"score_gpt":0.2244583399858942,"score_spread":0.2161660831666055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}