{"id":"W4415586443","doi":"10.1158/1078-0432.ccr-25-1459","title":"PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with <i>PIK3CA</i> -Mutated Solid Tumors and in Preclinical Models","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre; University Health Network; Discovery Centre","funders":"","keywords":"Precision oncology; Solid tumor; Cancer; Precision medicine; Cooperativity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003221016,0.0005027664,0.000602957,0.0002606818,0.000141396,0.000600812,0.0003537243,0.0002816861,0.002356939],"category_scores_gemma":[0.0002317304,0.0002025245,0.0005262317,0.0002372319,0.0002289459,0.0002909401,0.0001966734,0.001262374,0.0006048068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004521244,"about_ca_system_score_gemma":0.0004584055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004224692,"about_ca_topic_score_gemma":0.001333341,"domain_scores_codex":[0.9998569,0.00002311652,0.00001084313,0.00003165281,0.0000372999,0.00004007928],"domain_scores_gemma":[0.9998971,0.00001308556,0.00003137248,0.00001262785,0.000009414564,0.00003636539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01281807,0.005035575,0.003320153,0.0004620902,0.0002751996,0.0002768189,0.00009005138,0.002417551,0.871676,0.0004947411,0.002162624,0.1009712],"study_design_scores_gemma":[0.01162614,0.09094683,0.04300052,0.0001013743,0.0008846276,0.003582886,0.0001600387,0.009197454,0.8118517,0.0004852989,0.02809824,0.000064835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873685,0.004038163,0.001712404,0.0002899257,0.00008063009,0.0001917692,0.0003903014,0.0003159581,0.005612351],"genre_scores_gemma":[0.9953418,0.0009340819,0.001207469,0.0001042148,0.00002422186,0.00007452376,0.000631218,0.00002988535,0.001652666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002356939,"threshold_uncertainty_score":0.0078848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07439259426989839,"score_gpt":0.4929038867641238,"score_spread":0.4185112924942254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}