{"id":"W4415586443","doi":"10.1158/1078-0432.ccr-25-1459","title":"PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with <i>PIK3CA</i> -Mutated Solid Tumors and in Preclinical Models","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre; University Health Network; Discovery Centre","funders":"","keywords":"Precision oncology; Solid tumor; Cancer; Precision medicine; Cooperativity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002627334,0.0002283059,0.000478069,0.0003816781,0.000100008,0.00007939046,0.0003655757,0.0003352875,0.00001085709],"category_scores_gemma":[0.002125453,0.0001977617,0.00004479154,0.0007624173,0.000785305,0.00001875958,0.0006732319,0.001134455,0.000002822227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138079,"about_ca_system_score_gemma":0.0009982331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005722812,"about_ca_topic_score_gemma":0.003484952,"domain_scores_codex":[0.9955814,0.001129064,0.0007677025,0.001127225,0.0005686202,0.000825947],"domain_scores_gemma":[0.9978626,0.0008107077,0.00006015809,0.0005023446,0.0003775417,0.0003866748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01772009,0.0005983227,0.9630081,0.0001556993,0.00005166769,0.00002360928,0.000158585,0.0001398466,0.008234028,0.00001800334,0.002650648,0.007241365],"study_design_scores_gemma":[0.005941093,0.00342919,0.9347885,0.0008212437,0.000007949548,0.000001593308,0.0001406427,0.00037666,0.05264035,0.0002751445,0.001128945,0.0004486915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996587,0.0005871079,0.00002459326,0.001348416,0.00005334636,0.001114286,0.00008848411,0.00000952654,0.0001872714],"genre_scores_gemma":[0.9979569,0.0004708407,0.0001568027,0.0003619779,0.00007894948,0.0002643474,0.00003484204,0.00003541246,0.0006399332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04440632,"threshold_uncertainty_score":0.8064488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07439259426989839,"score_gpt":0.4929038867641238,"score_spread":0.4185112924942254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}