{"id":"W4415589078","doi":"10.1007/s00246-025-04070-6","title":"Bile Acid-Mediated Hepatic–Cardiac Axis in Fontan Chronotropy","year":2025,"lang":"en","type":"letter","venue":"Pediatric Cardiology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Cardiac surgery; Vascular surgery; Chronotropic; Fontan procedure; Cardiopulmonary bypass","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003661569,0.0006127792,0.001243516,0.0004376522,0.00006187891,0.00002546167,0.0006291841,0.002118222,0.00007881491],"category_scores_gemma":[0.0003880052,0.0006229318,0.0006388779,0.0004564695,0.0001383488,0.000003012778,0.0003697607,0.001007133,0.0001115829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003243668,"about_ca_system_score_gemma":0.0005931874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001795147,"about_ca_topic_score_gemma":0.00004446879,"domain_scores_codex":[0.9963552,0.0005745784,0.0006676143,0.001215802,0.0002590612,0.0009276867],"domain_scores_gemma":[0.9983388,0.0001134208,0.0002120254,0.00112758,0.0001161481,0.00009205181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004041184,0.00001618378,0.0392289,0.0001342685,0.000242222,0.0001101541,0.00001387822,0.00003386079,0.0008360271,0.000003816539,0.9583072,0.001033054],"study_design_scores_gemma":[0.0008296023,0.0001362687,0.009480787,0.000006536701,0.0003673819,0.00001205808,0.0000181445,0.000005551996,0.00023948,0.00007095229,0.9882046,0.0006286624],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.3834205,0.2685338,0.004050669,0.2294611,0.03433027,0.006533551,0.006710676,0.0003689802,0.06659042],"genre_scores_gemma":[0.1142836,0.1726868,0.001381168,0.5458871,0.1008057,0.002246113,0.04469245,0.0005348626,0.01748229],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3164259,"threshold_uncertainty_score":0.9996222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004759216759883203,"score_gpt":0.2211681754600107,"score_spread":0.2164089587001275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}