{"id":"W4415590751","doi":"10.1101/2025.10.24.25338566","title":"Cell-free DNA Whole Genome Sequencing for Non-Invasive Minimal Residual Disease Detection in Multiple Myeloma","year":2025,"lang":"","type":"preprint","venue":"medRxiv","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Sunnybrook Health Science Centre; University of New Brunswick; Vancouver General Hospital; Saint John Regional Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Minimal residual disease; Multiple myeloma; Whole genome sequencing; DNA sequencing; Bone marrow; Genome; Personalized medicine; Liquid biopsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008608338,0.0003455323,0.0003376353,0.0006519091,0.0001918304,0.0005989416,0.0003275468,0.0006501334,0.0008442948],"category_scores_gemma":[0.001621127,0.000177748,0.0002663824,0.0003296149,0.0002226338,0.000228755,0.0003969443,0.0004730469,0.0003994111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145081,"about_ca_system_score_gemma":0.0002915368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000948921,"about_ca_topic_score_gemma":0.001671931,"domain_scores_codex":[0.9994611,0.0001598466,0.00002366608,0.000169335,0.0001495939,0.00003632859],"domain_scores_gemma":[0.9993607,0.0003285163,0.0000974432,0.00006272977,0.0001048568,0.00004569048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006354263,0.0001191726,0.05068554,0.0002791305,0.0001690178,0.0001557897,0.0000930361,0.006336421,0.8390689,0.0005367917,0.001346495,0.1005743],"study_design_scores_gemma":[0.0001150607,0.001335051,0.2172502,0.0001236971,0.0002486235,0.001638004,0.0001352528,0.1536872,0.6090547,0.003440916,0.01287887,0.00009249857],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8908015,0.003870976,0.09852424,0.0004458083,0.0000659594,0.0001622397,0.003810797,0.001077838,0.001240528],"genre_scores_gemma":[0.9337474,0.000584951,0.062314,0.0002991153,0.00003262317,0.0001054888,0.002078417,0.00007062841,0.0007674824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000948921,"threshold_uncertainty_score":0.004552603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03806121162642923,"score_gpt":0.2930918505210073,"score_spread":0.2550306388945781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}