{"id":"W4415595419","doi":"10.1016/j.annonc.2025.10.1236","title":"Repertoire and clinical hierarchy of AR locus alterations in castration-resistant prostate cancer","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McMaster University; Queen's University; Hamilton Health Sciences; Occupational Cancer Research Centre; Ottawa Hospital; Health Sciences Centre; University Health Network; Abbotsford Veterinary Clinic; Jewish General Hospital; Sunnybrook Health Science Centre; Surrey Place Centre; Juravinski Cancer Centre; Canadian Centre for Applied Research in Cancer Control; Princess Margaret Cancer Centre; London Health Sciences Centre; Interior Health; BC Cancer Agency; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Genentech; BC Cancer Foundation; Ipsen; Syöpäsäätiö; Radboud Universitair Medisch Centrum; Astellas Pharma; Institute of Cancer Research; Terry Fox Research Institute; Michael Smith Health Research BC; Suomen Kulttuurirahasto; Academy of Finland; Eisai; EMD Serono; Jane ja Aatos Erkon Säätiö; Radboud Universiteit; Canadian Cancer Society; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Prostate Cancer Foundation","keywords":"Repertoire; Prostate cancer; Locus (genetics); Somatic cell; Hierarchy; Clinical significance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004856676,0.0001958582,0.0003964468,0.001408636,0.0002541523,0.0005011626,0.0003303001,0.0002642646,0.002002807],"category_scores_gemma":[0.00121526,0.000174811,0.0002810824,0.0008160096,0.0002812232,0.0001954139,0.0004143548,0.0002987478,0.0002590056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056657,"about_ca_system_score_gemma":0.0001931675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009244323,"about_ca_topic_score_gemma":0.001332545,"domain_scores_codex":[0.9995453,0.00007865131,0.00003542815,0.0001901733,0.0000901907,0.00006027864],"domain_scores_gemma":[0.9991745,0.0001970541,0.000315141,0.0001337247,0.00007610551,0.0001033526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004217713,0.0000253829,0.9762841,0.00003092042,0.0001404645,0.0001593668,0.00008906035,0.0001477352,0.0154432,0.00005122433,0.0001032102,0.007103511],"study_design_scores_gemma":[0.000006605887,0.00009582694,0.9973012,0.000004356771,0.00006261721,0.00103872,0.00005676719,0.0001832079,0.0009423769,0.0000531732,0.00025194,0.000003297039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998442,0.000528725,0.000256542,0.00001518735,0.000001575391,0.000007821221,0.0003787739,0.00002007445,0.0003493936],"genre_scores_gemma":[0.9992064,0.00007821899,0.0001132656,0.00001046035,0.000003372784,0.000003796349,0.0005198038,0.000006957336,0.00005781699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002807,"threshold_uncertainty_score":0.006700039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1149151734876534,"score_gpt":0.5037442646344384,"score_spread":0.388829091146785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}