{"id":"W4415595507","doi":"10.1101/2025.10.26.684662","title":"Unraveling the Mechanistic Links Between Blood Pressure Regulation and Calcium-Magnesium Homeostasis: Insights into Hypertension, Hyperparathyroidism, and Mineral Disorders","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Homeostasis; Blood pressure; Parathyroid hormone; Vitamin D and neurology; Renin–angiotensin system; Primary hyperparathyroidism; Aldosterone; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498563,0.000307281,0.000445023,0.000158448,0.0002464863,0.0005148536,0.0004947794,0.0006550683,0.001693529],"category_scores_gemma":[0.0003877181,0.0001883783,0.0003841936,0.0001498261,0.0005111668,0.0005063943,0.0004720397,0.0003537405,0.0001022538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177419,"about_ca_system_score_gemma":0.0009081232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007629924,"about_ca_topic_score_gemma":0.005484638,"domain_scores_codex":[0.9999603,0.0000143776,0.000001659206,0.000007395267,0.000008210999,0.000007979805],"domain_scores_gemma":[0.9999018,0.00004721129,0.00001337395,0.000009328336,0.00001148548,0.00001691155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00007908694,0.00006142321,0.003855281,0.00007438569,0.00004169246,0.000185997,0.00006159338,0.9691203,0.007824797,0.01414618,0.0003961629,0.004153183],"study_design_scores_gemma":[0.00002065462,0.00002732162,0.0008815425,0.000006747784,0.00001271876,0.00002302535,0.00003491744,0.9923424,0.0005989474,0.005364344,0.0006819696,0.000005493224],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8801361,0.0009586487,0.1045265,0.002127557,0.00009158951,0.00003219003,0.0004576744,0.0002139127,0.01145585],"genre_scores_gemma":[0.9873838,0.000465204,0.01038128,0.00009057665,0.00001773285,0.00002532427,0.00008738495,0.00002702324,0.00152162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007629924,"threshold_uncertainty_score":0.01517105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407524558963098,"score_gpt":0.2335994895505949,"score_spread":0.219524243960964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}