{"id":"W4415595725","doi":"10.1101/2025.10.26.684610","title":"Recapitulating Parkinson’s pathology in human iPSC dopaminergic neurons reveals new mechanistic insights into Lewy body formation and heterogeneity","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Neuropathology; Lewy body; Parkinson's disease; Alpha-synuclein; Genetic model; Dopaminergic; Synucleinopathies","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002386793,0.0002669048,0.000225159,0.0002199641,0.0001501867,0.0005296466,0.0002493288,0.0003402468,0.0006067508],"category_scores_gemma":[0.0001450625,0.0001000515,0.0002138535,0.0001279561,0.0002812253,0.00027053,0.0002841959,0.0007733506,0.0003156159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002298919,"about_ca_system_score_gemma":0.0001532327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005042547,"about_ca_topic_score_gemma":0.0004383914,"domain_scores_codex":[0.9998891,0.00001087366,0.00001692796,0.00002564068,0.00004358583,0.00001384183],"domain_scores_gemma":[0.9999015,0.00001738062,0.00002396429,0.00002480624,0.00001697919,0.00001538522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003288961,0.00002470854,0.0004023021,0.00003539936,0.000006338463,0.0001690891,0.0000402728,0.0003855476,0.9960432,0.0007450405,0.00009662969,0.002018658],"study_design_scores_gemma":[0.00001180199,0.0001083868,0.004946599,0.00001990171,0.00003154494,0.0005432857,0.00007084911,0.005983328,0.9819988,0.0006071524,0.00567013,0.000008300177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597384,0.001109077,0.0312493,0.0002321795,0.0001082307,0.0000661169,0.001452222,0.0002554949,0.005789022],"genre_scores_gemma":[0.9859282,0.001001644,0.009082253,0.0001104209,0.00001321513,0.00005248603,0.0010721,0.00006943753,0.002670273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006067508,"threshold_uncertainty_score":0.002029777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981721766615564,"score_gpt":0.2554790413558634,"score_spread":0.2356618236897078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}