{"id":"W4415603055","doi":"10.1083/jcb.202409169","title":"Moesin controls cell–cell fusion and osteoclast function","year":2025,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Agence Nationale de la Recherche; Wellcome Trust; Université Toulouse III - Paul Sabatier; National Institute of General Medical Sciences; Ligue Contre le Cancer; Fondation Toulouse Cancer Santé; Centre National de la Recherche Scientifique; European Molecular Biology Laboratory; Institut National de la Santé et de la Recherche Médicale; EMBL Australia; Fondation pour la Recherche Médicale; Cancer Research Foundation","keywords":"Osteoclast; Moesin; Cytoskeleton; Cell fusion; Multinucleate; Syncytium; Bone resorption; Lipid bilayer fusion; Actin cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229591,0.0002616911,0.0003068972,0.0002966012,0.0002225742,0.0005250313,0.0002406332,0.0004784293,0.001060577],"category_scores_gemma":[0.0001846178,0.0001828672,0.0002163253,0.00016143,0.0003535072,0.0003044879,0.0003763308,0.0005782962,0.0002641595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005475359,"about_ca_system_score_gemma":0.0002933818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007203951,"about_ca_topic_score_gemma":0.001001566,"domain_scores_codex":[0.9997326,0.00004142659,0.00003086012,0.00005092856,0.00007447065,0.00006977873],"domain_scores_gemma":[0.9998307,0.00002309126,0.00006283665,0.00001410314,0.00001646217,0.00005283454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001396285,0.00001910266,0.0001735159,0.00002224663,0.000003004059,0.00003025544,0.000008768701,0.00005048032,0.9984578,0.0002619965,0.00001539592,0.0008178034],"study_design_scores_gemma":[0.00002825268,0.0001719891,0.006170075,0.000007597653,0.00001472195,0.0002557001,0.00002922478,0.001350947,0.9887881,0.0001415498,0.003035231,0.000006629522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925326,0.00341734,0.002396955,0.0000732265,0.00001726971,0.00001705176,0.0001968144,0.00008730838,0.001261555],"genre_scores_gemma":[0.9966174,0.0005944117,0.0009491318,0.00002526781,0.000003323084,0.00001535757,0.0001403928,0.00001369817,0.001641054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060577,"threshold_uncertainty_score":0.003972709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003265445313791078,"score_gpt":0.2089690374575132,"score_spread":0.2057035921437221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}