{"id":"W4415603764","doi":"10.1002/chem.202502670","title":"Binding of Tetrapentylammonium to a c‐MYC G‐quadruplex Depicted through NMR and Volumetric Assessment","year":2025,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto","keywords":"Antiparallel (mathematics); Molecule; Molecular dynamics; Nuclear magnetic resonance spectroscopy; Characterization (materials science); Ligand (biochemistry); Two-dimensional nuclear magnetic resonance spectroscopy; Proton NMR","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701989,0.0002125312,0.0001116693,0.0001303074,0.0001209121,0.0001758901,0.0002255544,0.0002342734,0.0006530299],"category_scores_gemma":[0.0003558211,0.0001022351,0.0000895135,0.0001087193,0.0002771422,0.0001528561,0.000205492,0.0002883628,0.0001029444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002094519,"about_ca_system_score_gemma":0.00008970371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009444202,"about_ca_topic_score_gemma":0.0009041379,"domain_scores_codex":[0.9999099,0.00001439161,0.000003437775,0.0000182276,0.00003389954,0.00002019217],"domain_scores_gemma":[0.9998567,0.00004450928,0.00004197973,0.000008577003,0.00002726561,0.00002096893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002788286,0.000005431677,0.0001026415,0.000013477,0.000002262702,0.000009447689,0.00002076286,0.0002352707,0.9988334,0.00004182034,0.00001017065,0.0006975058],"study_design_scores_gemma":[0.000002849987,0.0001660933,0.001296548,0.000002730329,0.000004840558,0.00002569646,0.00003989323,0.005434394,0.9926412,0.00003116711,0.0003480062,0.000006650908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996206,0.0001391225,0.002991141,0.00001995388,0.000004063851,0.00001046692,0.00004830687,0.00002856105,0.000552309],"genre_scores_gemma":[0.9968442,0.0001211487,0.002350195,0.00001972589,0.000002738411,0.00001326404,0.00008037314,0.000005303403,0.0005630251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009444202,"threshold_uncertainty_score":0.00218457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007387032136654917,"score_gpt":0.2598357071224081,"score_spread":0.2524486749857532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}