{"id":"W4415609021","doi":"10.1093/brain/awaf410","title":"IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Rare Diseases Clinical Research Network; Muscular Dystrophy Association; National Institutes of Health; Myasthenia Gravis Foundation of America","keywords":"Autoantibody; Isotype; Myasthenia gravis; Antibody; Polyclonal antibodies; Acetylcholine receptor; Autoimmunity; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032652,0.0001761587,0.0004680804,0.0002303855,0.00005967121,0.000009870925,0.0001270131,0.0001410095,0.0001289697],"category_scores_gemma":[0.0001760021,0.000147342,0.0001546673,0.0002774619,0.0001412001,0.00003018052,0.00007447368,0.0001674519,0.00002880172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001853207,"about_ca_system_score_gemma":0.0001492677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004856259,"about_ca_topic_score_gemma":0.00002386878,"domain_scores_codex":[0.9988576,0.0000460794,0.0003703297,0.0002879885,0.0001567871,0.0002812619],"domain_scores_gemma":[0.9992487,0.0001040803,0.0001041539,0.0003703012,0.0000967052,0.00007603621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000191994,0.0003344759,0.002832809,0.0002335323,0.0001554163,0.0001687999,0.0005750026,6.636403e-7,0.5022258,0.4728917,0.002828899,0.01756095],"study_design_scores_gemma":[0.02222698,0.002990731,0.3262831,0.002720309,0.001160068,0.002274643,0.002565827,0.003046872,0.3120973,0.240494,0.08263696,0.00150323],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617049,0.0003194883,0.01266654,0.008069803,0.0003079165,0.0004425044,0.00006068845,0.00009772702,0.0163304],"genre_scores_gemma":[0.9871557,0.00001979999,0.005222913,0.001641025,0.0000463545,0.00001701855,0.00002094451,0.00001872965,0.005857487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3234502,"threshold_uncertainty_score":0.6008433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159976156779127,"score_gpt":0.2780284837325072,"score_spread":0.2664287221647159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}