{"id":"W4415609021","doi":"10.1093/brain/awaf410","title":"IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Rare Diseases Clinical Research Network; Muscular Dystrophy Association; National Institutes of Health; Myasthenia Gravis Foundation of America","keywords":"Autoantibody; Isotype; Myasthenia gravis; Antibody; Polyclonal antibodies; Acetylcholine receptor; Autoimmunity; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003260467,0.0004853709,0.0002646642,0.0008586993,0.0001744239,0.0005600308,0.0003002145,0.0004166708,0.001053034],"category_scores_gemma":[0.0003979687,0.0002034662,0.0002576711,0.0003045218,0.0003521202,0.0002994812,0.0004769972,0.0004213403,0.0003037607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315985,"about_ca_system_score_gemma":0.0001006785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006573689,"about_ca_topic_score_gemma":0.0006903642,"domain_scores_codex":[0.999765,0.00003919588,0.00001868582,0.00008648613,0.00004468262,0.00004595749],"domain_scores_gemma":[0.9997965,0.0000533655,0.00005569333,0.00003737997,0.00002637288,0.00003081262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004473772,0.00009243758,0.2783335,0.0002785292,0.0001358078,0.007361685,0.0005556078,0.0004200283,0.6658113,0.001025884,0.0008152894,0.04472249],"study_design_scores_gemma":[0.00006885211,0.0009750259,0.8442893,0.00009204297,0.0002370561,0.06075041,0.0004252697,0.002735149,0.0809031,0.001198295,0.008294141,0.00003131634],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931526,0.003180228,0.001705745,0.0001179941,0.00001857495,0.00001540085,0.0001427232,0.0001307755,0.001535947],"genre_scores_gemma":[0.9979932,0.0005543135,0.0008568839,0.00006622754,0.00003169159,0.000006374124,0.0001305228,0.000006484407,0.0003542531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053034,"threshold_uncertainty_score":0.003522754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159976156779127,"score_gpt":0.2780284837325072,"score_spread":0.2664287221647159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}