{"id":"W4415610122","doi":"10.3390/ijms262110440","title":"Dendritic Polyglycerol Sulfate Reduces Inflammation Through Inhibition of the HMGB1/RAGE Axis in RAW 264.7 Macrophages","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Freie Universität Berlin; Deutsche Forschungsgemeinschaft","keywords":"HMGB1; Nitric oxide; Nitric oxide synthase; Inflammation; Tumor necrosis factor alpha; Lipopolysaccharide; Rage (emotion); Mediator; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567946,0.0003512657,0.000322363,0.0002027384,0.0000820326,0.0002027135,0.0001388197,0.0002374797,0.0005566404],"category_scores_gemma":[0.00008029363,0.0001065648,0.000234957,0.0001338857,0.0001916006,0.0001710573,0.0001530763,0.0005141187,0.0001654857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000139264,"about_ca_system_score_gemma":0.0002294603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004704648,"about_ca_topic_score_gemma":0.0006738147,"domain_scores_codex":[0.999866,0.00002803854,0.0000142323,0.00001864634,0.00002867916,0.00004442848],"domain_scores_gemma":[0.9999313,0.000007868795,0.00002082332,0.000006194079,0.00001197842,0.00002180736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005290877,0.00009090837,0.00007454656,0.00004563564,0.000006282214,0.00002314597,0.00001097978,0.00003773806,0.9981259,0.00002137845,0.00003183376,0.001002631],"study_design_scores_gemma":[0.00008942851,0.002261438,0.002995951,0.000008696585,0.00003386425,0.00006999137,0.00004032035,0.0005708039,0.9925929,0.00004106337,0.001290468,0.000005123465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959973,0.001807775,0.001039061,0.000154196,0.00004321291,0.00002991575,0.0002205825,0.0000748141,0.0006332441],"genre_scores_gemma":[0.9941621,0.001627363,0.001492669,0.0001574158,0.00002129514,0.00005964331,0.0003777725,0.00001565223,0.002086012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005566404,"threshold_uncertainty_score":0.001862168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160899243451771,"score_gpt":0.3279139139903992,"score_spread":0.3163049215558815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}