{"id":"W4415612931","doi":"10.1016/j.toxrep.2025.102152","title":"Unvaporized e-liquid toxicity elevates CD44-dependent hyaluronan catabolic gene expression and triggers inflammation in human vocal fold fibroblasts","year":2025,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Deafness and Other Communication Disorders; National Institutes of Health; McGill University","keywords":"Inflammation; Extracellular matrix; Extracellular; Proinflammatory cytokine; Gene expression; Hyaluronan synthase; Hyaluronic acid; Intracellular; Catabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006466302,0.0002431089,0.000338849,0.0002392209,0.0001643676,0.00003271938,0.0001675519,0.0004342604,0.00003521779],"category_scores_gemma":[0.0002305218,0.0002350661,0.00006789312,0.0001935453,0.0001827803,0.00001424098,0.0003366464,0.0002453024,0.000001392919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007067212,"about_ca_system_score_gemma":0.0002654975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001158345,"about_ca_topic_score_gemma":0.0004568592,"domain_scores_codex":[0.9977872,0.0001981588,0.0006087854,0.0007216999,0.0001991916,0.0004849091],"domain_scores_gemma":[0.9990463,0.00002823976,0.0001872489,0.0005230243,0.00008704775,0.0001281122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004169467,0.0001013351,0.005733105,0.00004738707,0.00003139097,0.0002251015,0.00004295513,0.0000592706,0.9910992,0.00006535671,0.0002925883,0.001885353],"study_design_scores_gemma":[0.001154712,0.0007095045,0.00623086,0.00004585645,0.00001305858,0.0001485042,0.00002729252,0.00002846682,0.9878554,0.0002916981,0.003276085,0.0002185466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969337,0.0007070907,0.0004783555,0.0002500993,0.000160371,0.0006682981,0.00000894796,0.00002575169,0.0007673703],"genre_scores_gemma":[0.9975775,0.0001199847,0.0002897638,0.0001088498,0.000114592,0.0001960536,0.0002212975,0.00001985597,0.001352093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003243795,"threshold_uncertainty_score":0.9585717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008173888370203337,"score_gpt":0.2826439246018844,"score_spread":0.274470036231681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}