{"id":"W4415615711","doi":"10.1186/s40364-025-00850-7","title":"THSD4 is a novel mediator of T cell exclusion and anti-PD-1 resistance in hormone receptor-positive breast cancer","year":2025,"lang":"en","type":"article","venue":"Biomarker Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Beatrice Hunter Cancer Research Institute; Nova Scotia Health Authority; Acadia University; Dalhousie University","funders":"Killam Trusts; Canadian Cancer Society; Dalhousie University; Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Cancer Research Society; Dalhousie Medical Research Foundation; Research Nova Scotia; Beatrice Hunter Cancer Research Institute","keywords":"Breast cancer; Pembrolizumab; Immune system; Immunotherapy; Tumor microenvironment; Immune checkpoint; T cell; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003787229,0.0002495935,0.0004603015,0.0005134541,0.0002434201,0.0005831345,0.0002239359,0.0002458153,0.001649822],"category_scores_gemma":[0.0006121005,0.0001174077,0.0005744857,0.0009815355,0.0001881607,0.0001720496,0.0003696638,0.0003728904,0.0001866515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003157345,"about_ca_system_score_gemma":0.0003580214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184591,"about_ca_topic_score_gemma":0.001644912,"domain_scores_codex":[0.9997794,0.00004349091,0.0000218102,0.00007246187,0.00004804822,0.00003480321],"domain_scores_gemma":[0.9997368,0.00006968512,0.0001142835,0.00002078949,0.00002911867,0.00002933169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002524007,0.00009370675,0.9095868,0.0007286901,0.001328717,0.0004832937,0.0001085542,0.003176246,0.03970366,0.0004458295,0.003813683,0.03800685],"study_design_scores_gemma":[0.0001657973,0.0003980669,0.9704937,0.00008272281,0.001183735,0.001309424,0.0001709368,0.006740725,0.008915105,0.001389712,0.009127466,0.00002245788],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854414,0.004222938,0.001072972,0.0002982443,0.0000249942,0.0000238866,0.007833426,0.00005923712,0.001022977],"genre_scores_gemma":[0.9886934,0.0008937582,0.0008714468,0.0001862582,0.0000315331,0.0000307452,0.008793935,0.00001251226,0.0004863897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649822,"threshold_uncertainty_score":0.005519211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566022618823507,"score_gpt":0.3629876044686055,"score_spread":0.3273273782803705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}