{"id":"W4415617777","doi":"10.1002/cmdc.202500572","title":"Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of <sup>18</sup> F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3","year":2025,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Northern Alberta Institute of Technology; Alberta Cancer Foundation; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation","keywords":"Radioligand; Peptidomimetic; Pharmacophore; Muscarinic acetylcholine receptor; Reductive amination; Receptor; Radioligand Assay; Acetylcholine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002090859,0.0001924606,0.0003034559,0.00007469906,0.000120562,0.0000152738,0.0002289038,0.0001978699,0.0001312132],"category_scores_gemma":[0.0009826475,0.0001549075,0.00008851123,0.0002478317,0.000090293,0.000005606305,0.0001619851,0.0001179178,0.000001132412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004049253,"about_ca_system_score_gemma":0.0002915038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004843404,"about_ca_topic_score_gemma":0.000001824736,"domain_scores_codex":[0.9984884,0.0001102638,0.0005558918,0.0003334252,0.0002810259,0.0002310503],"domain_scores_gemma":[0.99884,0.0001104299,0.0002369341,0.000300119,0.0004625815,0.00004993378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007493278,0.00004655143,0.0002329559,0.0001024357,0.000176079,5.418623e-8,0.0004757781,0.0001909536,0.9837213,0.00003211347,0.0003074196,0.01463942],"study_design_scores_gemma":[0.0007871868,0.00003434451,0.00008515857,0.0001098905,0.0001329922,7.834121e-7,0.000865287,0.003333614,0.9928524,0.00004344546,0.001607532,0.0001473381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958917,0.002277895,0.0008569221,0.00006850386,0.0000945943,0.0003017522,0.000005478913,0.000009526759,0.0004935685],"genre_scores_gemma":[0.9933274,0.0002600677,0.005989633,0.00002541539,0.00009305369,0.00005450947,0.00006922827,0.00002083636,0.0001598592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01449208,"threshold_uncertainty_score":0.6316945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02381840937582835,"score_gpt":0.2781676683654246,"score_spread":0.2543492589895962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}