{"id":"W4415619535","doi":"10.1056/evidoa2500109","title":"Age and Treatment Intensification in Metastatic Hormone-Sensitive Prostate Cancer","year":2025,"lang":"en","type":"review","venue":"NEJM Evidence","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Prostate cancer; Radiation therapy; Cancer; Clinical trial; Patient data; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002302764,0.0003919226,0.001571101,0.0004087998,0.0000522438,0.00003187447,0.00007640001,0.0001151593,0.00001048611],"category_scores_gemma":[0.000261833,0.0002514025,0.0001742853,0.0006206359,0.0001490524,0.000120865,0.00006724841,0.0003016248,0.00002281186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001163629,"about_ca_system_score_gemma":0.001388846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000816528,"about_ca_topic_score_gemma":0.0002375528,"domain_scores_codex":[0.9981269,0.0002013514,0.0004524832,0.0006276314,0.0002494761,0.0003422051],"domain_scores_gemma":[0.9986411,0.0005604445,0.0001546372,0.0003626841,0.0001486665,0.0001324096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002045194,0.00007839328,0.0000866524,0.01128948,0.0002750738,0.0008912037,0.0005486367,1.897118e-7,0.00001515736,0.00001572006,0.0002269718,0.986368],"study_design_scores_gemma":[0.003170741,0.00160261,0.00344595,0.2890275,0.006388927,0.0001734978,0.0004328562,0.00004612666,0.00008674839,0.00006931679,0.6948035,0.000752232],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003865268,0.9950169,0.000003576791,0.0006694585,0.00007962713,0.003560529,0.00005899471,0.00003025904,0.0001941711],"genre_scores_gemma":[0.0005770493,0.9898044,0.0001126398,0.00006553517,0.00004981905,0.001569314,0.0001279586,0.00002822329,0.007665063],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9856158,"threshold_uncertainty_score":0.9999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.181017516789616,"score_gpt":0.4610676770126741,"score_spread":0.2800501602230582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}