{"id":"W4415625690","doi":"10.21203/rs.3.rs-4347593/v1","title":"Neuropeptide Y co-opts neuronal ensembles for memory lability and stability","year":2025,"lang":"","type":"preprint","venue":"Research Square","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation","funders":"ShanghaiTech University; Science and Technology Commission of Shanghai Municipality; Fudan University; National Natural Science Foundation of China; Shanghai Municipal Health Commission","keywords":"GABAergic; Engram; Excitatory postsynaptic potential; Inhibitory postsynaptic potential; Neuropeptide Y receptor; Hippocampal formation; Memory consolidation; Bursting; Interneuron","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733743,0.0003138686,0.0003416934,0.0001420059,0.0002047547,0.0008444625,0.0003574774,0.0004680775,0.002224629],"category_scores_gemma":[0.0005386804,0.0001507674,0.0002216635,0.0001195538,0.0003912124,0.0006820494,0.0007536832,0.0005886197,0.0003028449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801744,"about_ca_system_score_gemma":0.000248817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002763813,"about_ca_topic_score_gemma":0.0004041498,"domain_scores_codex":[0.9999207,0.000006015496,0.000006167206,0.00002366897,0.00001743918,0.00002593041],"domain_scores_gemma":[0.999769,0.00004023268,0.00006996725,0.00003236371,0.00002823204,0.00006017645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005987017,0.00004235061,0.001335264,0.00005340014,0.00004136159,0.0001391407,0.00002716561,0.001373623,0.9678596,0.002880835,0.0006448745,0.02500368],"study_design_scores_gemma":[0.0001838703,0.0005905178,0.03038714,0.00002663753,0.0001433331,0.0005237684,0.0002029255,0.0611716,0.877263,0.02629656,0.003158914,0.00005171371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745442,0.0008596884,0.0203772,0.0006384612,0.0003299067,0.00001131318,0.000116679,0.000220574,0.002901959],"genre_scores_gemma":[0.9956067,0.0002120374,0.002416986,0.00006159587,0.00003435606,0.000009614764,0.00004388498,0.00003306767,0.001581818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002224629,"threshold_uncertainty_score":0.007442117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2917915218247683,"score_gpt":0.466185730252576,"score_spread":0.1743942084278077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}