{"id":"W4415625950","doi":"10.1016/j.jim.2025.113930","title":"Determining reference values for the ALZPath plasma p-tau217 assay in a large cohort of elderly individuals with normal cognitive function","year":2025,"lang":"en","type":"article","venue":"Journal of Immunological Methods","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Reference values; Cohort; Cognition; Reference data; Cohort study; Reference range","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00254876,0.0009049545,0.0008155843,0.001879107,0.0009601059,0.00135296,0.000875968,0.001142232,0.0007656325],"category_scores_gemma":[0.00749837,0.000424552,0.0004196671,0.0009376776,0.0004857736,0.0005021631,0.0005940119,0.000704166,0.0005431111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004598404,"about_ca_system_score_gemma":0.0003381423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002944355,"about_ca_topic_score_gemma":0.002931768,"domain_scores_codex":[0.9984527,0.0004431741,0.0001679361,0.0004201626,0.000410874,0.0001051115],"domain_scores_gemma":[0.9976575,0.0009090208,0.0003538585,0.0003941528,0.0005473954,0.0001380466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002394673,0.0003032921,0.9681236,0.00006919249,0.000363699,0.0008097739,0.0009124807,0.0003739096,0.009197172,0.0002418623,0.001027699,0.01618265],"study_design_scores_gemma":[0.00009125187,0.0009006602,0.9889367,0.00003646382,0.0002701513,0.001811088,0.0004897662,0.002314364,0.002884582,0.0004079174,0.001836146,0.00002100731],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939725,0.001157211,0.002788078,0.0000629338,0.00005383296,0.00004236037,0.0003604283,0.00007988605,0.001482755],"genre_scores_gemma":[0.9976771,0.0001691978,0.001071791,0.00009282492,0.00003221356,0.00004940079,0.0005109704,0.00001971114,0.0003767855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002944355,"threshold_uncertainty_score":0.01347923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04807066810615995,"score_gpt":0.4173725035573084,"score_spread":0.3693018354511484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}