{"id":"W4415629984","doi":"10.1021/acs.jmedchem.5c01693","title":"Aza-Isotryptophan: Synthesis, Pictet–Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Peptide; Residue (chemistry); Triad (sociology); Receptor; Amino acid; Side chain; Cluster (spacecraft); Amino acid residue; Cyclic peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003051929,0.0004390594,0.0002182106,0.0002281044,0.0001723464,0.0002127386,0.0003325228,0.0003719561,0.001002245],"category_scores_gemma":[0.0001580447,0.0001599709,0.0001894067,0.0002882023,0.0002385031,0.0003979414,0.0001755093,0.0006354186,0.000475623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227877,"about_ca_system_score_gemma":0.0001690591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001815946,"about_ca_topic_score_gemma":0.0001591856,"domain_scores_codex":[0.9998806,0.00003483466,0.00001043212,0.00002285964,0.0000266815,0.00002458889],"domain_scores_gemma":[0.9999217,0.00001269811,0.00002676157,0.0000131814,0.000008917669,0.00001669711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001874631,0.00004290546,0.00005189086,0.00009733054,0.000007589625,0.0001391263,0.00004058088,0.0006466316,0.9934285,0.000800457,0.0001592094,0.004398246],"study_design_scores_gemma":[0.00001874862,0.0005370941,0.0003217208,0.000003787588,0.00000830071,0.0003339495,0.000006484006,0.0007414352,0.9952893,0.0000574727,0.002672445,0.000009242131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505121,0.00656177,0.0332166,0.0003387757,0.00009618703,0.000339109,0.0009155707,0.0003140238,0.007705788],"genre_scores_gemma":[0.9681594,0.00438539,0.02318631,0.0001193169,0.00003407938,0.0001530505,0.0004834026,0.0000336505,0.003445273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002245,"threshold_uncertainty_score":0.00335288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0088961036681844,"score_gpt":0.2358588923989016,"score_spread":0.2269627887307172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}