{"id":"W4415639271","doi":"10.1016/s2468-1253(25)00192-x","title":"Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Société Canadienne de Pédiatrie; GlaxoSmithKline","keywords":"Biliary tract; Clinical trial; Ursodeoxycholic acid; Primary (astronomy); Primary biliary cirrhosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001136859,0.001071375,0.002249837,0.00026493,0.0002620274,0.0007452787,0.0007345309,0.001732776,0.006019592],"category_scores_gemma":[0.001146562,0.0003696358,0.001614915,0.000345987,0.0007587297,0.0008346969,0.0003947553,0.00250292,0.0009984176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005564757,"about_ca_system_score_gemma":0.0005814548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007784012,"about_ca_topic_score_gemma":0.001494141,"domain_scores_codex":[0.9995446,0.0002405483,0.0000264575,0.00006643001,0.00003929884,0.00008266434],"domain_scores_gemma":[0.9995585,0.0001520815,0.0001076642,0.0000315997,0.00002611144,0.0001240089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9635721,0.001544894,0.0004815696,0.001820568,0.001483127,0.00007484621,0.00005600443,0.0002407147,0.003004562,0.0001521856,0.001639511,0.02592987],"study_design_scores_gemma":[0.973285,0.02371845,0.001516699,0.00005084552,0.0003240324,0.00005893916,0.00001647802,0.0001760258,0.0001710382,0.0001060941,0.000567489,0.000008927152],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654441,0.02362217,0.001092388,0.001816547,0.0009579035,0.002489887,0.001234631,0.0003134949,0.003028835],"genre_scores_gemma":[0.98213,0.006374296,0.001515025,0.00231597,0.000449272,0.002831264,0.001067791,0.00002866978,0.003287814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006019592,"threshold_uncertainty_score":0.02013755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531993385761376,"score_gpt":0.2787558225300883,"score_spread":0.2634358886724745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}